昂丹司琼对罗哌卡因蛛网膜下腔阻滞效能的影响

发布时间：2018-03-15 02:17

  本文选题：昂丹司琼　切入点：罗哌卡因　出处：《上海医学》2015年02期 　论文类型：期刊论文

【摘要】：目的观察昂丹司琼是否对罗哌卡因蛛网膜下腔阻滞的效能产生影响。方法随机选取择期行下肢手术的患者44例,将其随机分入昂丹司琼组和对照组,每组22例。昂丹司琼组患者于麻醉前15min静脉滴注昂丹司琼4mg,对照组患者则未予昂丹司琼。所有患者均行罗哌卡因蛛网膜下腔阻滞,有效标准:1蛛网膜下腔阻滞后20min感觉阻滞平面(针刺疼痛消失法)至少达到T12水平;2运动阻滞以蛛网膜下腔阻滞后20min双下肢阻滞达到Bromage Scale评分≥2分(0分为髋、膝、踝关节均可正常运动;1分为不能抬腿,但可以活动膝和踝关节;2分为不能活动膝关节,但可以活动踝关节;3分为髋、膝、踝关节均不能运动);3蛛网膜下腔阻滞后≥1h,硬脊膜外腔不再追加注射局部麻醉药物直至手术结束。根据序贯法公式计算两组患者罗哌卡因的半数有效量(ED50)及其95%CI。结果昂丹司琼组和对照组罗哌卡因的ED50及其95%CI分别为11.42(11.02~11.85)和11.32(10.92~11.80)mg,两组间差异无统计学意义(P0.05)。结论昂丹司琼对罗哌卡因蛛网膜下腔阻滞的效能无影响。
[Abstract]:Objective to observe the effect of ondansetron on the efficacy of ropivacaine subarachnoid block. Methods 44 patients undergoing elective lower limb surgery were randomly divided into ondansetron group and control group. Ondansetron group received intravenous infusion of ondansetron 4 mg 15 minutes before anesthesia, while the control group did not receive ondansetron. All patients received ropivacaine subarachnoid block. Effective standard: 1 the level of sensory block (acupuncture pain vanishing) reached T12 level at least 20 minutes after subarachnoid block and motor block was achieved at least 20 minutes after subarachnoid block. The score of Bromage Scale 鈮，

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