盐酸右美托咪定与异丙酚在无痛结肠镜检查中的麻醉效果和安全性比较

发布时间：2018-03-15 11:27

本文选题：盐酸右美托咪定　切入点：异丙酚　出处：《中国药房》2016年03期 　论文类型：期刊论文

【摘要】：目的:比较盐酸右美托咪定与异丙酚在无痛结肠镜检查中的麻醉效果和安全性。方法:80例拟行无痛结肠镜检查患者随机均分为A组和B组。A组患者30 s内泵注异丙酚负荷剂量1 mg/kg,后以6 mg/(kg·h)维持;B组患者5 min内微量泵缓慢泵注盐酸右美托咪定注射液负荷剂量0.3μg/kg,后以0.2~0.3μg/(kg·h)维持。观察两组患者检查前(T_0),给药后镜检开始前(T_1),镜检开始后1 min(T_2)、10 min(T_3),退镜完毕后1 min(T_4)、5 min(T_5)的平均动脉压(MAP)、心率(HR)、血氧饱和度(SPO_2)及呼吸频率(RR),麻醉起效时间、入镜时间、检查时间、离院时间,辅助使用芬太尼患者例数及不良反应发生情况。结果:A组患者T_1时的MAP显著低于同组T_0时,两组患者T_1~T_3时的HR均显著低于同组T_0时,差异均有统计学意义(P0.05),但两组患者各时点的SpO_2、RR比较,差异均无统计学意义(P0.05)。B组患者麻醉起效时间、辅助使用芬太尼患者例数、不良反应发生率均显著低于A组,差异均有统计学意义(P0.05)。结论:盐酸右美托咪定与异丙酚在无痛结肠镜检查中均有较好的麻醉效果,但盐酸右美托咪定安全性更好。
[Abstract]:Objective: to compare the anesthetic effect and safety of dexmetidine hydrochloride and propofol in painless colonoscopy. Methods: 80 patients with painless colonoscopy were randomly divided into group A and group B. The loading dose of propofol was 1 mg / kg, then 6 mg/(kg 路h). The loading dose of dexmetomidine hydrochloride injection was 0.3 渭 g / kg for 5 min and 0.2 渭 g / kg 路h for dexmetidine hydrochloride injection respectively. The mean arterial pressure (MAPP), heart rate (HRT), blood oxygen saturation (SPO _ 2) and respiratory frequency (RRN), the onset time of anesthesia, were observed at 1 min after the beginning and 1 min after the end of the endoscopy. Results the MAP of group 1 was significantly lower than that of T _ 0 in group A, and the HR at T _ 1T _ 3 in both groups was significantly lower than that of T _ 0 in group T _ (1) and T _ (1) T _ (3) in both groups, the number of patients with Fentanyl plus fentanyl and the incidence of adverse reactions were significantly lower than those in group T _ (1) and T _ (0). The difference was statistically significant (P 0.05), but there was no significant difference between the two groups in SpO2RR at different time points. There was no significant difference in the onset time of anesthesia, the number of patients with auxiliary use of fentanyl, and the incidence of adverse reactions were significantly lower in group B than in group A. Conclusion: dexmetidine hydrochloride and propofol have better anaesthesia effect in painless colonoscopy, but dexmetomidine hydrochloride is more safe.
【作者单位】：天津中医药大学第一附属医院;天津医科大学肿瘤医院麻醉科;
【分类号】：R614

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