右美托咪定对七氟烷麻醉后手术患儿的临床研究

发布时间：2018-03-18 04:19

本文选题：右美托咪定　切入点：七氟烷　出处：《中国临床药理学杂志》2015年23期 　论文类型：期刊论文

【摘要】：目的观察接受七氟烷麻醉时应用右美托咪定对患儿血流动力学、应激反应及苏醒期躁动的影响。方法 80例接受七氟烷麻醉的患儿随机分为试验组及对照组,每组40例。试验组完成麻醉及插管操作后静脉泵入右美托咪定1μg·kg-1·h-1,对照组给予等量0.9%Na Cl。比较2组麻醉前及麻醉中的心率、收缩压、舒张压、血糖、皮质醇浓度和肾上腺素浓度变化情况,并对2组麻醉苏醒期躁动评分比较。结果 2组麻醉前心率、收缩压、舒张压、血糖、皮质醇浓度和肾上腺素浓度差异无统计学意义(P0.05),而在麻醉10 min后,2组以上指标均较麻醉前有所升高,但试验组显著低于对照组(P0.05)。手术结束拔管时和患儿苏醒时,试验组躁动评分均明显低于对照组(P0.05)。结论在接受七氟烷麻醉时,右美托咪定可有效地稳定患儿的血流动力学,降低应激反应,改善苏醒期的躁动情况。
[Abstract]:Objective to observe the effects of dexmetomidine on hemodynamics, stress response and restlessness during sevoflurane anesthesia in children. Methods 80 children undergoing sevoflurane anesthesia were randomly divided into experimental group and control group. 40 patients in each group were given dexmetomidine 1 渭 g 路kg-1 路h-1.The heart rate, systolic blood pressure, diastolic blood pressure and blood glucose were compared before and after anesthesia in the control group. Results Heart rate, systolic blood pressure, diastolic blood pressure, blood glucose, heart rate, systolic blood pressure, blood glucose, heart rate, systolic blood pressure, blood glucose, heart rate, systolic blood pressure, diastolic blood pressure, blood glucose, heart rate, systolic pressure, diastolic blood pressure, There was no significant difference in cortisol concentration and epinephrine concentration between the two groups, but the above indexes in the two groups were higher than those before anesthesia 10 min after anesthesia, but they were significantly lower in the trial group than in the control group. The extubation at the end of the operation and the recovery of the children were significantly lower than those in the control group. Conclusion dexmetomidine can effectively stabilize hemodynamics, decrease stress response and improve restlessness in recovery period in patients with sevoflurane anesthesia, the scores of restlessness in the test group were significantly lower than those in the control group (P 0.05).
【作者单位】：山东潍坊医学院第二附属医院益都中心医院麻醉科;浙江大学医学院附属儿童医院麻醉科;
【基金】：2013年山东省医药卫生平台重点资助计划基金资助项目(2013ZDA011)
【分类号】：R726.1

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