芬太尼复合小剂量咪唑安定静脉麻醉用于妇产科门诊手术患者的疗效与安全性

发布时间：2018-04-01 09:17

本文选题：芬太尼　切入点：小剂量　出处：《中国药物经济学》2016年09期

【摘要】：目的探讨芬太尼复合小剂量咪唑安定静脉麻醉用于妇产科门诊手术患者的疗效与安全性。方法选取辽宁省辽阳市第四人民医院妇产科门诊自2013年6月至2015年10月收治的患者400例作为研究对象,采用随机数字表法分为观察组和对照组,各200例。对照组患者采取芬太尼进行静脉麻醉,观察组患者在芬太尼基础上,加用小剂量咪唑安定进行静脉麻醉,比较两组患者的麻醉效果及安全性。结果观察组患者的麻醉起效时间、麻醉苏醒时间均短于对照组,且芬太尼用量少于对照组,差异均有统计学意义(均P0.05),但两组患者的手术时间及不良反应发生率比较,差异均无统计学意义(均P0.05)。两组患者麻醉前、麻醉后最低值、手术结束、完全苏醒时的动脉血管饱和度(SaO_2)、呼吸频率(RR)、心率(HR)、平均动脉压(MAP)水平比较,差异均无统计学意义(均P0.05)。两组患者麻醉后最低值时的SaO_2、RR、HR、MAP水平与麻醉前比较,差异均有统计学意义(均P0.05);对照组患者手术结束时的SaO_2、RR水平与麻醉前比较,差异均有统计学意义(均P0.05)。观察组患者手术结束时和完全苏醒时的SaO_2、RR、HR、MAP水平均高于麻醉后最低值,差异均有统计学意义(均P0.05);对照组患者手术结束时HR、MAP水平,完全苏醒时的SaO_2、RR、HR、MAP水平均高于麻醉后最低值,差异均有统计学意义(均P0.05)。结论在妇产科门诊手术过程前,行芬太尼复合小剂量咪唑安定静脉麻醉的疗效显著,并且该麻醉方式安全性较高。
[Abstract]:Objective to investigate the efficacy and safety of fentanyl combined with low dose midazolam intravenous anesthesia in outpatient department of gynecology and obstetrics. Methods the outpatient department of gynecology and obstetrics of the fourth people's Hospital of Liaoyang City Liaoning Province from June 2013 to October 2015 was selected. 400 patients were treated as subjects. The patients in the control group were given intravenous anesthesia with fentanyl, and the patients in the observation group received intravenous anesthesia with small doses of midazolam on the basis of fentanyl. Results the onset time and recovery time of anesthesia in the observation group were shorter than those in the control group, and the dosage of fentanyl was less than that in the control group. The difference was statistically significant (P 0.05), but there was no significant difference in the time of operation and the incidence of adverse reactions between the two groups (P 0.05). Before anesthesia, the lowest value after anesthesia and the end of operation, the two groups had no significant difference (P 0.05). There was no significant difference in arterial blood vessel saturation (SAO), respiratory frequency (RRN), heart rate (HRT) and mean arterial pressure (MAPP) between the two groups (all P 0.05), and there was no significant difference between the two groups at the lowest value after anaesthesia (P < 0.05), and the level of SaO2RRN HRMAP at the lowest value after anaesthesia was higher than that before anesthesia, and no significant difference was found between the two groups. There were significant differences between the two groups (all P 0.05), and the levels of SaO2RR at the end of operation in the control group were significantly higher than those before anesthesia (P 0.05). The levels of SaO2RRHRHR map in the observation group were higher than those in the control group at the end of operation and at the time of complete recovery. The level of HRMAP at the end of operation in the control group and the HRMAP level in SaO2RRN in patients with complete recovery were all higher than the lowest level after anesthesia (all P 0.05). Conclusion before the operation of outpatient department of gynecology and obstetrics, the HRMAP level of the patients in the control group was significantly higher than that of the lowest value after anesthesia (all P 0.05). Fentanyl combined with small dose midazolam intravenous anesthesia was effective and safe.
【作者单位】：辽宁省辽阳市第四人民医院;
【分类号】：R614.2

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