乳腺手术患者围术期抗菌药物使用干预效果研究

发布时间：2018-04-03 22:23

本文选题：抗菌药物　切入点：乳腺手术　出处：《中华医院感染学杂志》2015年20期

【摘要】：目的研究临床药师对乳腺手术患者围术期抗菌药物干预的效果,评价临床药师在围术期抗菌药物合理性使用中的干预作用。方法采用回顾性调查方法,随机抽取2010-2011年167例(非干预组)及2012年158例(干预组)乳腺手术患者,对抗菌药物使用的合理性进行评价,应用SPSS 15.0进行统计分析。结果经临床药师干预,乳腺手术患者围术期预防性应用抗菌药物在预防使用率、药物选择、联合用药、用药时机与疗程等方面较干预前均有明显改善,抗菌药物预防使用率由干预前的93.41%下降至干预后10.76%;非干预组术前30min~2h或麻醉开始时给药分布率为3.85%,干预后提高至11.76%;非干预组抗菌药物预防使用品种主要以β-内酰胺酶抑制剂为主,其次为选用单环β-内酰胺类抗菌药物;非干预组中有84例存在联合使用抗菌药物,全部为二联用药,干预后联合用药为0。结论经过抗菌药物专项整治,抗菌药物不合理应用的现象得到显著改善,但在药物选择、使用时间等方面仍需要继续改进。
[Abstract]:Objective to study the effect of clinical pharmacists on perioperative antimicrobial intervention in patients undergoing breast surgery, and to evaluate the intervention effect of clinical pharmacists in the rational use of perioperative antimicrobial agents.Methods A retrospective study was carried out on 167 patients (non-intervention group) in 2010-2011 and 158 cases (intervention group) in 2012. The rationality of the use of antimicrobial agents was evaluated. SPSS 15.0 was used for statistical analysis.Results after intervention by clinical pharmacists, the prophylactic use of antimicrobial agents in perioperative period of breast surgery patients was significantly improved in terms of preventive utilization rate, choice of drugs, combined use of drugs, timing and course of treatment, and so on.The second was monocyclic 尾 -lactam antibiotics, and 84 cases in non-intervention group had combined use of antimicrobial agents, all of which were combined drugs, and after intervention, the combined use of antibiotics was 0. 5%.Conclusion the irrational use of antimicrobial agents has been significantly improved through special treatment of antimicrobial agents, but it still needs to be improved in the aspects of drug selection and use time.
【作者单位】：南通市肿瘤医院药剂科;
【基金】：南通市科技基金资助项目(HS12945)
【分类号】：R969.3

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