罗哌卡因在超声引导肋间神经阻滞用于乳腺良性肿块切除术中的半数有效浓度

发布时间：2018-04-04 06:54

本文选题：罗哌卡因　切入点：乳房切除术　出处：《中国新药与临床杂志》2017年07期

【摘要】：目的测定罗哌卡因在超声引导下肋间神经阻滞用于乳腺良性肿块切除术中的半数有效浓度(EC50)。方法选择拟行单侧乳腺良性肿块切除术女性患者32例,ASAⅠ或Ⅱ级,在超声引导下用罗哌卡因行肋间神经阻滞麻醉。罗哌卡因浓度根据序贯法确定,初始浓度为0.25%,若阻滞效果完全,下一例患者降低浓度0.05%;若阻滞效果不完全,下一例患者升高浓度0.05%。采用Probit概率单位回归法计算罗哌卡因的EC50及其95%可信区间(CI),观察记录患者一般情况及不良反应发生情况。结果患者退出3例,完成试验共29例,年龄(38.1±10.7)岁,体重指数(23.7±3.2)kg·m~(-2)。神经阻滞完成至手术开始时间为(14.2±3.3)min,手术持续时间为(101.6±24.4)min。罗哌卡因用于超声引导下肋间神经阻滞的EC50为0.210 9%(95%CI:0.150 1%~0.268 9%)。未见严重不良反应发生。结论罗哌卡因在超声引导肋间神经阻滞用于乳腺良性肿块切除术中的EC50为0.210 9%。
[Abstract]:Objective to determine the median effective concentration (EC50) of ropivacaine in benign breast mass resection with intercostal nerve block guided by ultrasound.Methods 32 female patients with unilateral benign breast mass resection were treated with ropivacaine under intercostal nerve block under ultrasound guidance.The concentration of ropivacaine was determined by sequential method. The initial concentration of ropivacaine was 0.25. If the blocking effect was complete, the next patient would decrease the concentration of 0.05 and if the blocking effect was not complete, the next patient would rise to a high concentration of 0.05.The EC50 of ropivacaine and its 95% confidence interval were calculated by Probit probabilistic unit regression method.Results three patients quit, 29 patients (age: 38.1 卤10.7) years old, body mass index (BMI) 23.7 卤3.2)kg map-2.The time from the completion of nerve block to the beginning of operation was 14.2 卤3.3 minutes, and the duration of operation was 101.6 卤24.4 minutes.The EC50 of ropivacaine for intercostal nerve block guided by ultrasound was 0.210 9%(95%CI:0.150.No serious adverse reactions occurred.Conclusion the EC50 of ropivacaine in ultrasonic guided intercostal nerve block for benign breast mass resection is 0.210 9.
【作者单位】：深圳市龙岗区人民医院麻醉科;
【基金】：深圳市知识创新计划-基础研究项目(JCYJ20150402164314693)
【分类号】：R614

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