小剂量右美托咪定预处理抑制舒芬太尼诱发的呛咳

发布时间：2018-04-05 17:14

本文选题：右美托咪定　切入点：舒芬太尼　出处：《实用医学杂志》2015年01期

【摘要】：目的:评价麻醉诱导期使用小剂量右美托咪定预处理对舒芬太尼诱发呛咳的抑制作用。方法:105例全麻下行甲状腺次全切除手术患者被随机分成三组。对照组、实验组1(D1组)和实验组2(D2组)在麻醉诱导期分别接受生理盐水、0.25μg/kg右美托咪定和0.5μg/kg右美托咪定静脉注射。输注完毕后3组患者均给予0.3μg/kg舒芬太尼静脉注射。记录注射芬太尼后1 min内呛咳的发生情况和强度;记录各组从静脉输注右美托咪定到气管插管后1 min期间的BP和HR。结果:3组呛咳发生率分别为27.0%、8.3%和6.2%。与对照组相比,D1组和D2组的呛咳总发生率和中、重度呛咳发生率明显减少(P0.05)。与对照组相比,D1组低血压和心动过缓的发生率无明显增加(P0.05),但D2组的心动过缓发生率较对照组增多(P0.05)。结论 :麻醉诱导期静脉注射小剂量右美托咪定可抑制舒芬太尼诱发呛咳,使气管插管更平稳。
[Abstract]:Aim: to evaluate the inhibitory effect of low dose dexmetomidine preconditioning on choking cough induced by sufentanil during induction of anesthesia.Methods 105 patients with subtotal thyroidectomy under general anesthesia were randomly divided into three groups.The control group (1(D1 group) and the 2(D2 group (group 2(D2) received intravenous injection of dexmetidine (0.25 渭 g/kg) and dexmetidine (0.5 渭 g/kg) respectively during the induction period of anesthesia.All the patients in the 3 groups were given sufentanil (0.3 渭 g/kg) intravenously after infusion.The incidence and intensity of choking cough were recorded 1 min after fentanyl injection, BP and HR1 min after endotracheal intubation were recorded from intravenous infusion of dexmetidine to 1 min after tracheal intubation.Results the incidence of choking cough in the three groups was 27.0% and 6.2%, respectively.Compared with the control group, the total incidence of cough and the incidence of severe cough in group D 1 and group D 2 were significantly lower than those in group D 1 and group D 2 (P 0.05).Compared with the control group, the incidence of hypotension and bradycardia in group D 1 was not significantly increased, but the incidence of bradycardia in group D 2 was higher than that in group D 2.Conclusion: intravenous injection of dexmetidine in anesthetic induction period can inhibit cough induced by sufentanil and make tracheal intubation more stable.
【作者单位】：广东省开平市中心医院麻醉科;中山大学附属第三医院麻醉科;
【基金】：广东省自然科学基金资助(编号:S2012040006569)
【分类号】：R614

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