盐酸戊乙奎醚对深低温停循环全弓置换术微循环的影响

发布时间：2018-04-06 01:12

本文选题：深低温停循环　切入点：盐酸戊乙奎醚　出处：《临床麻醉学杂志》2015年01期

【摘要】：目的探讨盐酸戊乙奎醚对深低温停循环全弓置换术微循环的影响。方法选择全麻下30例深低温停循环(DHCA)选择性脑灌注行Bentall+全弓置换术患者,随机均分为两组,盐酸戊乙奎醚组(P组)和对照组(C组),P组在右锁骨下动脉完成插管后予盐酸戊乙奎醚3mg,恢复全身CPB后再给予盐酸戊乙奎醚3mg,C组予以等量生理盐水;于麻醉诱导后(T0)、中心体温(食管温)降至22°时(T1)、降主动脉远端开放即刻(T2)、降主动脉远端开放30min(T3)、CPB 3h(T4)、关胸后(T5)分别取动脉血测乳酸值、取静脉血测静脉血氧饱和度(SvO2),并记录相应时间点尿量、血管活性药物用量。结果 P组T2~T5时乳酸明显低于C组(P0.05),T2~T5时SvO2明显高于C组(P0.05),T2~T5时尿量明显多于C组(P0.05)。结论盐酸戊乙奎醚对深低温停循环全弓置换术似有改善微循环水平的作用。
[Abstract]:Objective to investigate the effect of pentehyclidine hydrochloride on microcirculation in deep hypothermia circulatory arrest total arch replacement.Methods 30 patients with Bentall total arch replacement were randomly divided into two groups.Group P (group P) and group C (control group) were treated with pentanosine hydrochloride (3mg / g) after the right subclavian artery was intubated, and group C (group C) was given the same amount of normal saline after the recovery of the whole body of CPB.After anesthesia induction, the central body temperature (esophageal temperature) dropped to 22 掳T _ (1), the distal end of descending aorta was opened immediately and T _ (2), the distal end of descending aorta was opened for 30 min, CPB ~ (3 h) T _ (4) was removed, and the arterial blood lactate was measured after thoracic closure.Venous blood was taken to measure the venous oxygen saturation and the volume of urine and the dosage of vasoactive drugs were recorded.Results the SvO2 of group P was significantly higher than that of group C (P 0.05). The urine volume of group P was significantly higher than that of group C (P 0.05).Conclusion Penehyclidine hydrochloride may improve the level of microcirculation in deep hypothermia circulatory arrest total arch replacement.
【作者单位】：郑州大学第二附属医院麻醉科;
【基金】：河南省卫生厅科技攻关项目(201204026) 河南省科技厅重点攻关项目(122300410075)
【分类号】：R614

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