不同剂量右美托咪定用于腰硬联合麻醉下肢手术的术中镇静效果

发布时间：2018-04-14 07:13

本文选题：临床观察 + 下肢手术　；参考：《临床医学工程》2016年12期

【摘要】：目的探讨下肢手术采用不同剂量右美托咪定腰硬联合麻醉的术中镇静效果。方法选择2014年6月至2016年1月我院收治的下肢手术病人300例,随机分为对照组和观察组,每组150例。观察组予以0.5μg/kg右美托咪定腰硬联合麻醉,对照组予以0.25μg/kg右美托咪定联合腰硬麻醉,记录给药前(T_0)、给药5 min(T_1)、给药30 min(T_2)、给药1 h(T_3)、结束手术时(T_4)的呼吸频率(RR)、平均动脉压(MAP)、心率(HR)等指标情况以及术中镇静效果。结果观察组T_1、T_2、T_3、T_4时的RR、MAP、HR等指标均显著优于对照组,差异有统计学意义(P0.01);观察组T_1、T_2、T_3、T_4时的镇静效果均显著优于对照组,差异有统计学意义(P0.01)。结论下肢手术病人予以0.5μg/kg右美托咪定腰硬联合麻醉术中生命体征平稳,镇静效果较佳,值得临床推广。
[Abstract]:Objective to investigate the effect of combined spinal epidural anesthesia with different doses of dexmetidine in lower extremity surgery.Methods from June 2014 to January 2016, 300 patients with lower extremity operation were randomly divided into control group and observation group with 150 cases in each group.The observation group was given 0.5 渭 g/kg dexmetidine combined with spinal-epidural anesthesia, while the control group was given 0.25 渭 g/kg dexmetomidine combined with spinal-epidural anesthesia.The respiratory frequency, mean arterial pressure (MAPP), heart rate (HRR) and sedative effect were recorded before administration, 5 minutes after administration, 30 minutes after administration, 30 minutes after administration, 1 hour after administration, 1 hour after administration, and at the end of operation.Results the RRMP-MAPHR in the observation group was significantly better than that in the control group at T _ 1 / T _ 2 / T _ 3 / T _ T _ 4, and the sedation effect of the observation group was significantly better than that of the control group at the time of T _ 1 / T _ 2 / T _ 3 / T _ 4, and the difference was statistically significant (P 0.01), and that of the observation group was significantly better than that of the control group at the time of T _ 1 / T _ 2 / T _ 3 / T _ 3 / T _ 4.Conclusion 0.5 渭 g/kg dexmetomidine combined with Spinal-epidural Anesthesia has stable vital signs and good sedation effect in patients undergoing lower extremity surgery. It is worth popularizing in clinic.
【作者单位】：广东省廉江市人民医院麻醉科;
【分类号】：R614

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