地佐辛与氟比洛芬酯对乳腺癌围术期镇痛效果与免疫抑制的影响

发布时间：2018-04-18 22:39

  本文选题：乳腺肿瘤 + 围术期　； 参考：《重庆医学》2015年14期

【摘要】：目的探讨地佐辛与氟比洛芬酯对乳腺癌围术期镇痛效果与免疫抑制的影响。方法选取该院外科乳腺癌择期手术患者76例,在相同麻醉诱导和维持用药基础上,采用随机数字表法将患者分为观察组(n=40)和对照组(n=36),观察组患者麻醉诱导前给予地佐辛,对照组患者麻醉诱导前给予氟比洛芬酯,比较两组患者围术期镇痛效果和免疫抑制的影响。结果观察组术后3.0、6.0、12.0h视觉模拟疼痛评分(VAS)和Ramsay镇静评分明显低于对照组,两组比较差异有统计学意义(P0.05)。麻醉前,T淋巴细胞亚群(CD4+、CD8+、CD4+/CD8+)和NK细胞(CD16+CD56+)的组间比较差异无统计学意义(P0.05),观察组手术开始1.5h时,CD16+CD56+明显高于对照组,手术结束后24.0h,CD4+、CD4+/CD8+和CD16+CD56+明显高于对照组,两组比较差异有统计学意义(P0.05),且手术开始1.5h、手术结束后24.0h的上述指标均明显低于麻醉前,不同时段比较差异有统计学意义(P0.05),两组患者术后不良反应发生率比较差异无统计学意义(P0.05)。结论地佐辛对乳腺癌围术期镇痛效果和免疫抑制预防作用明显优于氟比洛芬酯。
[Abstract]:Objective to investigate the effect of dizosin and flurbiprofen on perioperative analgesia and immunosuppression of breast cancer.Methods Seventy-six patients with breast cancer undergoing elective operation were divided into two groups: observation group (n = 40) and control group (n = 36), on the basis of the same anesthetic induction and maintenance medication. The patients in the observation group were given dizosin before anesthesia induction.Patients in the control group were treated with flurbiprofen before anesthesia induction, and the analgesic effect and immunosuppressive effect were compared between the two groups.Results the visual analogue pain score (VASS) and Ramsay sedation score in the observation group were significantly lower than those in the control group (P 0.05).There was no significant difference between the T lymphocyte subsets (CD4 / CD8 / CD8) and NK cell CD16 CD56 (P 0.05). At 1.5 h after operation, the CD16 CD56 in the observation group was significantly higher than that in the control group, and the ratio of CD4 / CD8 and CD16 CD56 in the observation group was significantly higher than that in the control group at 24.0h after operation.The difference between the two groups was statistically significant (P 0.05), and the above indexes were significantly lower than those before anesthesia at the beginning of operation 1.5 hours and 24.0h after operation.There was no significant difference in the incidence of postoperative adverse reactions between the two groups (P 0.05).Conclusion the analgesic effect and immunosuppressive effect of dizosin on breast cancer is better than flurbiprofen ester.
【作者单位】： 广东省云浮]，

本文编号：1770432