舒芬太尼抑制双腔气管插管心血管反应的半数有效效应室浓度

发布时间：2018-04-23 18:36

本文选题：舒芬太尼 + 丙泊酚　；参考：《临床麻醉学杂志》2015年04期

【摘要】：目的通过序贯法测定咪达唑仑复合丙泊酚靶控输注下舒芬太尼在双腔气管插管中抑制心血管反应的半数有效效应室浓度(EC50)。方法选择全身麻醉下行左侧双腔气管插管的胸科非心脏手术患者,诱导时舒芬太尼目标靶控效应室浓度根据序贯法原则设定,当出现6个交叉点时终止试验。双腔气管插管心血管反应阳性的标准:在双腔气管插管5min内患者HR或MAP升高超过基础值的20%。结果实际21例患者纳入统计。舒芬太尼抑制双腔气管插管心血管反应的EC50:Dixon-Mood法计算为0.34ng/ml(95%CI:0.33~0.36ng/ml);Probit回归模型测得为0.34ng/ml(95%CI:0.31~0.37ng/ml)。结论咪达唑仑复合丙泊酚靶控输注下,舒芬太尼抑制双腔气管插管心血管反应的EC50为0.34ng/ml。
[Abstract]:Objective to determine the EC50 of midazolam combined with propofol target-controlled infusion of sufentanil in the inhibition of cardiovascular response in dual tracheal intubation by sequential method. Methods Non-cardiac patients undergoing left double-lumen endotracheal intubation under general anesthesia were selected. During induction sufentanil target target effect chamber concentration was set according to the principle of sequential method and the test was terminated when 6 intersections appeared. Criteria for positive cardiovascular response to dual endotracheal intubation: HR or MAP increases in patients with dual endotracheal intubation 5min by more than 20.1% of the baseline value. Results 21 patients were included in the statistics. The EC50:Dixon-Mood method for sufentanil inhibition of cardiovascular response to dual endotracheal intubation was calculated as 0.34 ng / ml / ml 95% CI: 0.33% 0.36 ng / ml ~ (-1) probit regression model and 0.34 ng / ml ~ (95) CI: 0.31% 0.37 ng / ml ~ (-1) 路ml ~ (-1) 路min ~ (-1) 路min ~ (-1). Conclusion the EC50 of sufentanil in inhibiting cardiovascular response to dual tracheal intubation was 0.34 ng / ml under midazolam combined with propofol target controlled infusion.
【作者单位】：四川省人民医院麻醉科;
【分类号】：R614

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