地佐辛对2型糖尿病腹腔镜胆囊切除术患者血浆胰岛素和血糖的影响

发布时间：2018-04-29 04:27

本文选题：地佐辛 + 型糖尿病　；参考：《广东医学》2015年21期

【摘要】：目的探讨地佐辛对2型糖尿病腹腔镜胆囊切除术患者血糖的影响。方法择期腹腔镜胆囊切除手术的2型糖尿病患者60例,随机均分为两组(n=30),地佐辛组于麻醉诱导后静脉注射地佐辛0.1 mg/kg,对照组于麻醉诱导后静脉注射生理盐水5 m L。麻醉诱导顺序用药为咪达唑仑-丙泊酚-舒芬太尼-顺阿曲库铵,丙泊酚4~6 mg/(kg·h)及瑞芬太尼0.15~0.3μg/(kg·min)维持麻醉,比较两组患者麻醉前,气管插管后、手术30 min、术毕、术后2 h和术后6 h的血糖和血浆胰岛素水平。结果地佐辛组患者各时间点空腹血糖水平与麻醉前相比差异无统计学意义(P0.05);对照组患者手术30 min至术后6 h血糖水平与麻醉前比明显升高,且同时间点血糖水平高于地佐辛组,差异有统计学意义(P0.05);与麻醉前相比,地佐辛组患者术后6 h血浆胰岛素水平升高,对照组患者手术30 min至术后6 h血浆胰岛素水平均明显升高,差异有统计学意义(P0.05);对照组患者手术30 min至术后6 h血浆胰岛素水平均高于地佐辛组(P0.05)。结论糖尿病手术患者气管插管前静脉注射地佐辛0.1 mg/kg能够更好地稳定围手术期血糖,降低术后胰岛素的抵抗。
[Abstract]:Objective to investigate the effect of dizosin on blood glucose in type 2 diabetic patients undergoing laparoscopic cholecystectomy. Methods Sixty patients with type 2 diabetes undergoing laparoscopic cholecystectomy were randomly divided into two groups: dizosin group was given dizosin 0.1 mg / kg intravenously after anesthesia induction, and control group was treated with saline 5 mL after anesthesia induction. Midazolam, propofol, sufentanil, propofol for 6 mg/(kg and remifentanil for 0. 15 ~ 0. 3 渭 g/(kg) were used to induce anesthesia. Blood glucose and plasma insulin levels were measured at 2 h and 6 h postoperatively. Results there was no significant difference in fasting blood glucose level between the two groups at different time points (P 0.05), and the blood glucose level in the control group was significantly higher than that in the control group from 30 min to 6 h after anesthesia, and at the same time, the blood glucose level in the control group was higher than that in the dizosin group at the same time point. The difference was statistically significant (P 0.05), compared with that before anesthesia, the plasma insulin level in the dizoxin group was higher than that in the control group, and that in the control group was significantly higher than that in the control group from 30 min to 6 h after operation. The plasma insulin level in the control group was higher than that in the dizoxin group from 30 min to 6 h after operation. Conclusion intravenous injection of dizosin 0.1 mg/kg before endotracheal intubation in diabetic patients can stabilize perioperative blood glucose and reduce insulin resistance.
【作者单位】：南京中医药大学附属中西医结合医院、江苏省中医药研究院麻醉科;
【分类号】：R587.1;R657.4

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