七氟醚吸入麻醉对急性颅内出血开颅手术患者的脑保护作用

发布时间：2018-05-02 04:22

本文选题：七氟醚 + 颅内出血　；参考：《实用医学杂志》2017年02期

【摘要】：目的:探讨七氟醚对急性颅内出血开颅手术患者的脑保护作用。方法:选择60倒急性开颅内出血手术患者,随机分为对照组和试验组各30倒,全麻下行开颅手术,对照组(C组)采用丙泊酚+瑞芬太尼静脉输注全麻,试验组(S组)采用七氟醚+丙泊酚+瑞芬太尼静吸复合全麻。观察不同时点血清C反应蛋白(CRP)、血清S-100β、NSE、IL-6、TNF-α水平及颅内压的变化。结果:S组和C组血清CRP 1 d之后均显著下降,且S组明显低于C组(P0.05)。S组和C组T_0-T_3血清S-100β、NSE水平、血清IL-6、TNF-α水平呈上升趋势(P0.05),S组T_1-T_3明显低于C组(P0.05)。S组和C组颅内压T_1之后均显著下降(P0.05),T_3时点C组明显回升(P0.05),且明显高于S组(P0.05)。结论:七氟醚可抑制急性颅内出血开颅手术患者炎症反应,具有一定的脑保护作用。
[Abstract]:Objective: to investigate the protective effect of sevoflurane on patients with acute intracranial hemorrhage after craniotomy. Methods: sixty patients with acute intracranial hemorrhage were randomly divided into control group (30 cases) and trial group (30 cases). General anesthesia was performed under general anesthesia and group C was treated by intravenous infusion of propofol remifentanil. Group S: sevoflurane propofol remifentanil combined with general anesthesia. The changes of serum C-reactive protein (C-reactive protein), serum S-100 尾 -NSENSE-6TNF- 伪 and intracranial pressure were observed at different time points. Results the levels of serum CRP in group S and group C were significantly lower than those in group C (P 0.05) and group C (P 0.05), and the levels of T_0-T_3 in group S were significantly lower than those in group C (P 0.05) and group C (P < 0.05). The level of serum IL-6 + TNF- 伪 increased. The T_1-T_3 of group P0.05 was significantly lower than that of group C (P 0.05) and group C (group C) was significantly lower than that of group C (P 0.05) and significantly higher than that of group S (P 0.05). Conclusion: sevoflurane can inhibit inflammatory reaction in patients undergoing craniotomy with acute intracranial hemorrhage.
【作者单位】：广州医科大学附属乐从医院麻醉科;
【分类号】：R614.2

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