硫酸镁联合复方利多卡因乳膏对丙泊酚麻醉下瑞芬太尼抑制双腔支气管插管反应的半数有效量

发布时间：2018-05-08 00:29

本文选题：硫酸镁 + 复方利多卡因乳膏　；参考：《临床麻醉学杂志》2015年01期

【摘要】：目的测定硫酸镁联合复方利多卡因乳膏对丙泊酚麻醉下瑞芬太尼抑制双腔支气管插管反应的半数有效量(ED50)。方法选择择期行开胸手术的患者,诱导前缓慢静注硫酸镁30mg/kg,其后以15mg·kg-1·h-1速率静脉输注直至插管完毕,双腔支气管导管囊套及前2/3均匀涂抹复方利多卡因乳膏2~3g,依次静注丙泊酚2.0mg/kg、顺苯磺酸阿曲库铵0.3mg/kg及瑞芬太尼进行麻醉诱导并插入双腔支气管导管,观察插管反应的发生情况。瑞芬太尼的剂量按序贯法确定,相邻剂量的比值为1.2。结果瑞芬太尼抑制插管反应的ED50为0.91μg/kg,95%可信区间为0.80~1.04μg/kg。结论硫酸镁联合复方利多卡因乳膏在丙泊酚麻醉下,瑞芬太尼抑制双腔支气管插管反应的ED50为0.91μg/kg,95%可信区间为0.80~1.04μg/kg。
[Abstract]:Objective to determine the half effective dose of magnesium sulfate combined with compound lidocaine cream for remifentanil in inhibiting double lumen bronchial intubation under propofol anesthesia. Methods the patients undergoing elective thoracotomy were treated with 30 mg / kg magnesium sulfate before induction, followed by intravenous infusion of magnesium sulfate at the rate of 15mg kg-1 h-1 until intubation was completed. Double lumen bronchial duct capsule and compound lidocaine cream were evenly smeared with compound lidocaine cream for 2g / 3g before 2 / 3, followed by intravenous injection of propofol 2.0 mg / kg, 0.3mg/kg and remifentanil respectively for anesthesia induction and insertion of double-lumen bronchial catheter to observe the occurrence of intubation reaction. The remifentanil dose was determined by sequential method and the ratio of adjacent doses was 1.2. Results the ED50 of remifentanil in inhibiting intubation response was 0.91 渭 g / kg ~ 95% CI = 0.800.04 渭 g 路kg ~ (-1) 路kg ~ (-1) 路kg ~ (-1) 路kg ~ (-1). Conclusion under propofol anesthesia, the ED50 of remifentanil in combination with compound lidocaine cream is 0.91 渭 g / kg ~ 95% confidence interval of 0.80 渭 g / kg ~ (-1) 渭 g / kg ~ (-1) 路kg ~ (-1).
【作者单位】：广西医科大学第一附属医院心血管病研究所导管手术麻醉室;
【分类号】：R614

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