不同全麻方式对腹腔镜结肠癌切除术患者围麻醉期T淋巴细胞亚群的影响研究

发布时间：2018-05-10 05:51

本文选题：麻醉 + 腹腔镜　；参考：《中国内镜杂志》2017年09期

【摘要】：目的研究不同全麻方式对腹腔镜结肠癌切除术患者围麻醉期T淋巴细胞亚群的影响。方法选取2008年3月-2012年6月于该院接受腹腔镜结肠癌切除术的患者80例,按照全麻方式的不同分为3组,接受静脉全麻的患者共28例(A组);接受吸入全麻的患者共25例(B组);接受静吸复合全麻的患者共27例(C组)。检测3组患者围麻醉期的T淋巴细胞亚群水平并进行对照研究。结果 3组患者全麻后均出现CD3~+、CD4~+和CD8~+水平降低,B组的CD4~+/CD8~+和NK细胞水平均明显降低,C组的CD4~+/CD8~+明显降低。B组患者T1、T2的各指标均明显低于A组,C组患者T1的CD3~+和CD8~+水平明显低于A组,T2除NK细胞外其他各指标均明显低于A组,另外C组患者T1的CD8~+明显低于B组,NK细胞明显高于B组,T2的CD4~+明显高于B组。结论静脉全麻对于腹腔镜结肠癌切除术患者围麻醉期T淋巴细胞亚群影响最小,对免疫功能的影响最为轻微。
[Abstract]:Objective to study the effect of different general anesthesia methods on T lymphocyte subsets in patients undergoing laparoscopic colon cancer resection. Methods from March 2008 to June 2012, 80 patients undergoing laparoscopic colon cancer resection in our hospital were divided into 3 groups according to different general anesthesia methods. A total of 28 patients received intravenous general anesthesia, 25 patients received general anesthesia, 25 patients received general anesthesia, and 27 patients received intravenous anesthesia combined with general anesthesia. The T lymphocyte subsets were measured in 3 groups of patients during the perianaesthesia period and a control study was carried out. Results after general anesthesia, the levels of CD3 ~ + CD4 ~ and CD8- ~ in group B were significantly lower than those in group A, and the levels of CD4 ~ / CD8 ~ and NK cells in group B were significantly lower than those in group A and group C. the T _ 1T _ 2 levels in group B were significantly lower than those in group A and C, respectively. The level of CD8 ~ was significantly lower than that of group A except NK cells, and the level of CD8 ~ was significantly lower than that of group A. In addition, the CD8- ~ of T _ 1 in group C was significantly lower than that in group B, which was significantly higher than that in group B and T _ 2. Conclusion intravenous general anesthesia has the least effect on T lymphocyte subsets and the least effect on immune function in patients undergoing laparoscopic colon cancer resection.
【作者单位】：山东省青岛市城阳区人民医院麻醉科;
【分类号】：R614;R735.35

【相似文献】