隆朋对手术犬免疫功能的抑制作用

发布时间：2018-05-13 15:36

本文选题：隆朋 + 犬　；参考：《西安交通大学学报(医学版)》2017年02期

【摘要】：目的探讨隆朋麻醉、手术应激对犬机体免疫功能的影响。方法选取健康犬14只,随机分为单纯隆朋麻醉组(A组,n=7)和隆朋麻醉手术组(B组,n=7),A组按3.0mg/kg肌肉注射隆朋进行麻醉,B组在A组基础上进行腹腔探查术,观察两组麻醉前(0h)和麻醉后2、8、24、72、120和168h血清IL-1β、IL-2、IL-4、IL-8、TNF-α含量的变化。结果与麻醉前相比,A组犬在麻醉后2~72h期间血清IL-1β、IL-2、TNF-α水平显著降低(P0.05),并且在120~168h期间逐渐恢复至麻醉前水平,而麻醉后血清IL-4、IL-8水平无明显变化(P0.05)。与麻醉前相比,B组犬在麻醉后2~168h期间血清IL-1β、IL-2水平显著降低(P0.05),而血清IL-8、TNF-α水平显著升高(P0.05)。与A组麻醉后同一时间点相比,B组犬在2、8、24、72、120、168h时血清IL-1β、IL-2水平显著降低(P0.05),而IL-8、TNF-α水平显著升高(P0.05)。结论隆朋麻醉、手术创伤应激反应均可导致犬免疫功能抑制,并且手术的影响要大于麻醉。
[Abstract]:Objective to investigate the effect of Longpene anesthesia and surgical stress on the immune function of dogs. Methods Fourteen healthy dogs were randomly divided into two groups: group A (group A) and group B (group B). Group A was treated with intramuscular injection of Longpene (group A) and group B (group A) underwent abdominal exploration on the basis of intramuscular injection of Longpene (group A). The changes of serum IL-1 尾 -IL-2 IL-4 IL-4 and TNF- 伪 levels before and after anesthesia were observed in both groups. Results compared with before anesthesia, the serum levels of IL-1 尾 and IL-2TNF- 伪 decreased significantly in group A at 72 h after anesthesia, and gradually recovered to the level before anesthesia at 120-168h, but the level of IL-4 IL-8 did not change significantly after anesthesia. Compared with before anesthesia, the serum IL-1 尾 -IL-2 level decreased significantly in group B at 2h after anesthesia, while the level of serum IL-8 TNF- 伪 increased significantly (P0.05A). Compared with group A at the same time point after anesthesia, the serum level of IL-1 尾 and IL-2 in group B decreased significantly at 721 068 h after anesthesia, while the level of IL-8 TNF- 伪 increased significantly (P 0.05). Conclusion Longpene anesthesia and surgical trauma stress can result in the inhibition of immune function in dogs, and the effect of operation is greater than that of anesthesia.
【作者单位】：延边大学附属医院麻醉科;
【分类号】：S859.791

【相似文献】