帕瑞昔布钠对瑞芬太尼快通道麻醉患者术后苏醒期影响的效果分析

发布时间：2018-05-14 18:06

本文选题：帕瑞昔布钠 + 瑞芬太尼　；参考：《中国临床药理学杂志》2015年09期

【摘要】：目的探讨麻醉诱导前用帕瑞昔布钠对瑞芬太尼快通道麻醉患者术后苏醒期的影响。方法将105例腹腔镜胆囊切除术患者随机分为3组,每组35例。A组在麻醉诱导之前20 min静脉输注帕瑞昔布钠40 mg+0.9%氯化钠10mL,B组在术毕前20 min静脉输注帕瑞昔布钠40 mg+0.9%氯化钠10 mL,C组在麻醉诱导前20 min静脉注射0.9%氯化钠10 mL。记录并比较不同时间点3组患者平均动脉压、心率、血氧饱和度以及口述描述痛觉评分、躁动评分、镇静评分和舒适度评分等。结果 T2至T4时间段,A组和B组平均动脉压、心率、躁动评分均显著低于C组,A组平均动脉压、心率、躁动评分显著低于B组(P0.05)。A组和B组镇静评分均显著高于C组,A组镇静评分显著高于B组(P0.05)。不同时间点口述描述痛觉评分比较,A组B组均显著低于C组,A组显著低于B组(P0.05)。A组和B组术后舒适度评分显著高于C组,A组术后舒适度评分显著高于B组(P0.05)。结论术前用帕瑞昔布钠能够明显减轻瑞芬太尼快通道麻醉患者的急性疼痛,有效抑制痛觉过敏,减少患者的苏醒期躁动。
[Abstract]:Objective to investigate the effect of paroxib sodium on postoperative recovery of patients undergoing remifentanil fast channel anesthesia before anesthesia induction. Methods 105 patients undergoing laparoscopic cholecystectomy were randomly divided into 3 groups. 35 patients in each group received 40 mg paroxib sodium 40 mg 0.9% sodium chloride 10 mL / L intravenously 20 min before anesthesia induction. Group B received paroxib sodium 40 mg 0.9% sodium chloride 10 mL (10 mL) 20 min before the end of the operation. 20 min before anesthesia induction, 0.9% sodium chloride 10 mL was injected intravenously. The mean arterial pressure, heart rate, oxygen saturation, oral description pain score, restlessness score, sedation score and comfort score were recorded and compared at different time points. Results the mean arterial pressure, heart rate and restlessness score in group A and B were significantly lower than those in group A and group C from T2 to T4. The score of restlessness was significantly lower than that of group B (P 0.05). Group A and group B were significantly higher than group C (group A) than group B (P 0.05). Comparison of oral description of pain scores at different time points in group A group B were significantly lower than those in group C and group A were significantly lower than those in group B and group B were significantly higher than those in group C and group A were significantly higher than those in group B (P 0.05). Conclusion preoperative use of paroxib sodium can significantly reduce the acute pain in patients with remifentanil fast channel anesthesia, effectively inhibit hyperalgesia and reduce restlessness during recovery.
【作者单位】：宁波市鄞州二院麻醉科;
【分类号】：R614

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