连续多次应用丙泊酚复合维生素C对小鼠麻醉效应的影响

发布时间：2018-05-22 20:07

本文选题：丙泊酚 + 维生素C　；参考：《南方医科大学学报》2015年12期

【摘要】：目的探讨连续6 d给予丙泊酚或丙泊酚配伍维生素C对小鼠的麻醉效果。方法取40只昆明鼠随机分为丙泊酚80 mg/kg组(P80组)、丙泊酚70 mg/kg+维生素C50 mg/kg组(P70+Vc50组)、丙泊酚55 mg/kg+维生素C100 mg/kg组(P55+Vc100组)、丙泊酚50 mg/kg+维生素C200 mg/kg组(P50+Vc200组),共4组,各组小鼠10只,以腹腔注射给药的方式,在同一时间点连续6 d给药,观察并记录小鼠麻醉诱导时间以及维持时间,并进行比较。结果与同天的丙泊酚组(P80)相比,给药的第1、2、3天的P55+Vc100组、P50+Vc200组麻醉维持时间缩短(P0.05)。与同一组第1天麻醉维持时间相比,各组小鼠其余5 d麻醉维持时间均缩短(P0.01);与同一组第2天麻醉维持时间相比,第3天P50+Vc200组麻醉维持时间缩短(P0.01),各组小鼠第4、5、6天麻醉维持时间均缩短(P0.01)。各组小鼠翻正反射消失的发生率由第1~6天逐渐下降,且各组趋势接近一致。结论维生素C与丙泊酚配伍,可在保证麻醉效果的前提下一定程度减少丙泊酚使用剂量,同时可减少丙泊酚耐受的发生,对于减少丙泊酚麻醉剂量相关的副作用或不良反应。
[Abstract]:Objective to investigate the anesthetic effect of propofol or propofol combined with vitamin C on mice for 6 days. Methods Forty Kunming rats were randomly divided into four groups: propofol 80 mg/kg group, propofol 70 mg/kg vitamin C 50 mg/kg group, propofol 55 mg/kg vitamin C 100 mg/kg group, P55 Vc100 group, propofol 50 mg/kg vitamin C 200 mg/kg group, P50 Vc200 group. The induction time and maintenance time of anesthesia in mice were observed and recorded by intraperitoneal injection for 6 days at the same time point. Results compared with the propofol group (P80) on the same day, the maintenance time of anesthesia in the P55 Vc100 group and P50 Vc200 group was shorter than that in the P55 Vc100 group on the 3rd day. Compared with the maintenance time of anesthesia on the first day of the same group, the rest of the mice in each group shortened the maintenance time of anesthesia on the other 5 days, compared with the maintenance time of anesthesia on the second day of the same group. On the 3rd day, the maintenance time of anesthesia in P50 Vc200 group was shortened (P 0.01), and the maintenance time of anesthesia in each group was shortened on day 4, 5 and 6 (P 0.01). The incidence of the disappearance of righting reflex in each group decreased gradually from day 1 to day 6, and the trend of each group was close to the same. Conclusion the combination of vitamin C and propofol can reduce the dosage of propofol and reduce the incidence of propofol tolerance on the premise of ensuring the anesthetic effect, and can reduce the side effects or adverse reactions related to the dose of propofol anesthesia.
【作者单位】：解放军总医院麻醉手术中心;军事医学科学院放射与辐射医学研究所;解放军第307医院麻醉科;
【基金】：国家自然科学基金(81371232) 国家科技重大专项(2014ZX09J14107-05B)~~
【分类号】：R614

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