七氟醚与异氟醚吸入麻醉对直肠癌根治术后患者认知功能的影响

发布时间：2018-05-26 23:19

本文选题：七氟醚 + 异氟醚　；参考：《中国乡村医药》2016年02期

【摘要】：目的探讨七氟醚和异氟醚吸入麻醉对直肠癌根治术后患者认知功能影响的差异。方法选取2012年1月至2015年3月来该院行直肠癌根治术的患者100例,按照入院先后顺序分为对照组和观察组各50例。对照组术中采用异氟醚麻醉,观察组采用七氟醚麻醉。记录两组手术时间和术后睁眼时间,在术前和术后1、12和24小时使用简易智能精神状况检查量表(MMSE)评估患者的认知功能,观察术后不良反应的发生情况。结果两组手术时间及不良反应发生率比较差异均无统计学意义;观察组睁眼时间显著短于对照组,术后1、12小时,两组的MMSE评分逐渐升高,但均显著低于术前,术后24小时观察组的MMSE评分已恢复到术前水平,对照组仍略低于术前;术后各时间点观察组的MMSE评分均显著高于对照组,差异有统计学意义。结论七氟醚和异氟醚均可损害直肠癌患者术后认知功能,但七氟醚比异氟醚对认知功能的损害较小。
[Abstract]:Objective to investigate the difference of cognitive function between sevoflurane and isoflurane after radical resection of rectal cancer. Methods 100 patients with radical resection of rectal cancer from January 2012 to March 2015 were selected and divided into the control group and the observation group, 50 cases in the control group. The control group was anaesthetized with isoflurane, and the observation group was used in the control group. Sevoflurane anesthesia. Records two groups of operation time and postoperative eye opening time, before and after the operation and 1,12 and 24 hours after the use of simple intelligent mental state examination scale (MMSE) to evaluate the cognitive function of the patients and observe the occurrence of adverse reactions after the operation. Results there were no significant differences between the two groups of operation time and the incidence of adverse reaction. The time of eye opening was significantly shorter than that of the control group. The MMSE score of the two groups increased gradually at 1,12 hours after the operation, but all was significantly lower than that before the operation. The MMSE score of the observation group had recovered to the preoperative level 24 hours after the operation, and the control group was still slightly lower than that before the operation, and the MMSE scores of the observation group were significantly higher than those in the control group after the operation, and the difference was statistically significant. Seven Fluoride and isoflurane both impaired the postoperative cognitive function of patients with rectal cancer, but sevoflurane had less damage to cognitive function than isoflurane.
【作者单位】：浙江长兴县中医院麻醉科;
【分类号】：R614;R735.37

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