罗哌卡因复合舒芬太尼应用于腰麻-硬膜外联合阻滞麻醉在分娩镇痛中的应用效果

发布时间：2018-05-28 14:08

本文选题：罗哌卡因 + 舒芬太尼　；参考：《中国医药科学》2016年12期

【摘要】：目的探讨罗哌卡因复合舒芬太尼应用于腰麻-硬膜外联合阻滞麻醉在分娩镇痛中的效果。方法选取2014年2月~2015年11月我院产科收治的自然分娩产妇200例为研究对象,将产妇住院号录入计算机采用随机抽签分组方法分为A组(单纯罗哌卡因)、B组(单纯舒芬太尼)、C组(罗哌卡因复合舒芬太尼)、D组(对照组),比较A、B、C三组产妇起效时间、首剂量持续时间、疼痛评分、局麻药总用量,四组产妇产程时间、不良妊娠结局(器械助产、剖宫产、新生儿窒息、产后出血)及药物不良反应。结果三组产妇疼痛评分无统计学意义(P0.05);B、C两组起效时间短于A组,首剂量持续时间长于A组,C组产妇局麻药总用量少于A组,比较有统计学意义(P0.05)。A、B、C三组产妇第一产程均短于D组(P0.05),三组产妇第一产程比较无统计学意义(P0.05);四组产妇第二产程、第三产程时间比较无统计学意义(P0.05)。四组产妇器械助产、剖宫产、新生儿窒息及产后出血不良妊娠结局发生率比较无统计学意义(P0.05)。四组患者在低血压、皮肤瘙痒、尿潴留、恶性呕吐药物不良反应发生率上比较无统计学意义(P0.05)。结论罗哌卡因复合舒芬太尼应用于腰麻-硬膜外麻醉在分娩镇痛中应用具有显著镇痛效果,可降低局麻药物使用剂量,具有较高应用安全性。
[Abstract]:Objective to investigate the effect of ropivacaine combined with sufentanil on labor analgesia. Methods from February 2014 to November 2015, 200 pregnant women with natural delivery were selected. The puerpera was divided into group A (ropivacaine group B) (simple sufentanil group C) (ropivacaine combined with sufentanil group D) (control group, control group). Duration of first dose, pain score, total dosage of local anesthetic, duration of labor, adverse pregnancy outcome (instrument delivery, cesarean section, neonatal asphyxia, postpartum hemorrhage) and adverse drug reactions. Results there was no significant difference in pain score among the three groups. The onset time of the two groups was shorter than that of group A, and the duration of the first dose was longer than that of group A, and the total dosage of local anesthetic in group C was less than that in group A. The first stage of delivery in three groups was shorter than that in group D, but there was no significant difference in the first stage of delivery among the three groups, but there was no significant difference in the second stage of labor and the time of the third stage of delivery in the four groups. There was no significant difference in the incidence of adverse pregnancy outcome among the four groups: instrument delivery, cesarean section, asphyxia neonatorum and postpartum hemorrhage. The incidence of adverse drug reactions such as hypotension, pruritus, retention of urine and malignant vomiting in the four groups was not statistically significant (P 0.05). Conclusion ropivacaine combined with sufentanil has a significant analgesic effect in labor analgesia, can reduce the dosage of local anesthetic, and has higher safety.
【作者单位】：广东省中山市黄圃人民医院麻醉科;
【基金】：广东省中山市医学科研项目(2015A020034)
【分类号】：R714.3

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