红花黄色素对实验性脑缺血的保护作用

发布时间：2018-05-29 02:15

本文选题：红花黄色素 + 脑缺血　；参考：《时珍国医国药》2017年11期

【摘要】：目的观察红花黄色素对实验性脑缺血的保护作用。方法线栓法建立大鼠急性脑缺血模型,分为溶剂对照组、红花黄色素组和阳性对照组,术后24h行神经功能缺损评分;大鼠连续给药7天后,用伊文思蓝渗出法测定大鼠脑血管的通透性;Beagle犬麻醉手术后,放置流量探头在颈内静脉和椎动脉,分别记录给药后15、30、60、90、120和180min脑血流量的变化,并检测Beagle犬离体心脑血管的张力变化。结果注射用红花黄色素对犬心脏、脑血管环的舒张作用分别为31.6%和73.1%;中剂量组(27.6%±7.36%)和高剂量组(21.9%±8.25%)的脑梗死面积较溶剂对照组(38.0%±9.07%)明显降低;治疗组脑内伊文思蓝的浸出量(9.87%±1.60)较溶剂对照组(12.0%±1.69)明显减少;6mg/kg红花黄色素给药后脑血流量15min内明显增加。结论红花黄色素对脑血管作用的选择性高,较低剂量能显著降低急性脑缺血引起的脑梗面积;静脉注射不仅能降低血管通透性,还能增加脑血流量。
[Abstract]:Objective to observe the protective effect of safflower yellow pigment on experimental cerebral ischemia. Methods Rat models of acute cerebral ischemia were established by thread embolization, and were divided into three groups: solvent control group, safflower yellow pigment group and positive control group. The permeability of cerebral vessels in rats was measured by Evans blue exudation method. After anesthesia, flow probe was placed in the internal jugular vein and vertebral artery, and the changes of cerebral blood flow (CBF) were recorded in 1530U 6090120 and 180min, respectively. The tension changes of isolated cardiac and cerebrovascular vessels in Beagle dogs were detected. Results the relaxation effects of safflower yellow for injection on heart and cerebrovascular ring were 31.6% and 73.1%, respectively, and the cerebral infarction area in middle dose group (27.6% 卤7.36%) and high dose group (21.9% 卤8.25%) was significantly lower than that in solvent control group (38.0% 卤9.07%). The leachate of Evans blue in the brain of the treatment group was 9.87% 卤1.60%, which was significantly lower than that of the solvent control group (12.0% 卤1.69). The cerebral blood flow (15min) was significantly increased after the administration of safflower yellow pigment at a dose of 6 mg / kg in the treatment group. Conclusion the effect of safflower yellow on cerebral vessels is highly selective and low dose can significantly reduce the area of cerebral infarction induced by acute cerebral ischemia and intravenous injection can not only reduce the permeability of blood vessels but also increase the cerebral blood flow.
【作者单位】：无锡卫生高等职业技术学校;
【基金】：江苏省无锡市医院管理中心医学科研面上项目(YGZXM1409)
【分类号】：R285.5

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