乌司他丁对胃肠道术后炎性因子与外周血T淋巴细胞亚群的作用探讨

发布时间：2018-05-30 22:07

本文选题：乌司他丁 + 胃肠道术　；参考：《世界最新医学信息文摘》2016年87期

【摘要】：目的研究乌司他丁对胃肠道术后炎性因子与外周血T淋巴细胞亚群的作用。方法病例资料来源于我院2013年4月至2015年7月就诊的70例胃肠道手术患者。随机分组方法随机数字表法。70例患者分为参照组和乌司他丁组。参照组手术麻醉诱导前静滴5%葡萄糖氯化钠注射液;乌司他丁组手术麻醉诱导前静滴乌司他丁。方法术前、术后患者炎性因子与外周血T淋巴细胞亚群的差异。结果 (1)术前两组患者炎性因子差异不显著,P0.05;术后1天两组IL-6、IL-8、IL-10、C反应蛋白以及TNF-α均上升,术后3天IL-6、IL-8、IL-10、C反应蛋白以及TNF-α均下降,而术后乌司他丁组患者炎性因子IL-6、IL-8、IL-10、C反应蛋白以及TNF-α上升或下降幅度均明显优于参照组,P0.05。(2)术前两组患者外周血T淋巴细胞亚群差异不显著,P0.05;术后两组患者外周血T淋巴细胞亚群指标CD8+均降低,但两组差异不显著,P0.05;术后乌司他丁组对比参照组外周血T淋巴细胞亚群指标CD4+以及CD4+/CD8+改善更显著,P0.05。结论乌司他丁对胃肠道术后炎性因子与外周血T淋巴细胞亚群的作用大,可有效促进机体炎性介质释放,改善细胞免疫功能,提升机体抵抗力,减轻手术所致应激和功能性器官损害。
[Abstract]:Objective to study the effects of ulinastatin on inflammatory factors and T lymphocyte subsets in peripheral blood after gastrointestinal surgery. Methods from April 2013 to July 2015, 70 patients underwent gastrointestinal surgery in our hospital. Methods A total of 70 patients were randomly divided into reference group and ulinastatin group. The control group received 5% glucose sodium chloride injection before anesthesia induction, and ulinastatin group received ulinastatin intravenous drip before anesthesia induction. Methods before and after operation, the difference between inflammatory factors and T lymphocyte subsets in peripheral blood was observed. Results (1) there was no significant difference in inflammatory factors between the two groups before operation (P 0.05), but on the first day after operation, the levels of IL-6, IL-8, IL-10, C-reactive protein and TNF- 伪 in the two groups increased, but on the 3rd day after operation, the levels of IL-6, IL-8, IL-10, C-reactive protein and TNF- 伪 decreased. However, the increase or decrease of IL-6, IL-8, IL-10, C-reactive protein and TNF- 伪 in Ulinastatin group was significantly higher than that in control group (P0.05. 2) there was no significant difference in T lymphocyte subsets of peripheral blood between the two groups before and after operation (P 0.05), and there was no significant difference in T lymphocyte subsets in peripheral blood between the two groups after operation (P < 0.05). The lymphocyte subsets (CD8) were all decreased. However, there was no significant difference between the two groups (P 0.05), and the improvement of CD4 and CD4 / CD8 was more significant in ulinastatin group than in the control group (P 0.05). Conclusion Ulinastatin has great effect on inflammatory factors and T lymphocyte subsets in peripheral blood after gastrointestinal tract operation, which can effectively promote the release of inflammatory mediators, improve cellular immune function and enhance body resistance. Stress and functional organ damage caused by operation were alleviated.
【作者单位】：河北省开滦总医院林西医院普外科;
【分类号】：R614

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