地佐辛用于下肢骨折患者椎管内麻醉前的镇痛效果评价

发布时间：2018-05-31 18:49

本文选题：下肢骨折 + 麻醉体位　；参考：《中国医院药学杂志》2015年11期

【摘要】：目的:观察地佐辛对下肢骨折患者行椎管内麻醉前体位摆放时的镇痛效果。方法:选择80例因下肢骨折拟在椎管内麻醉下行择期手术患者,采用随机、双盲法分为地佐辛组(DEZ组,n=40)和对照组(n=40)。椎管内麻醉体位摆放前15min,DEZ组肌肉注射地佐辛10 mg(2 ml),对照组肌肉注射0.9%氯化钠2 ml。记录2组患者安静平卧位时(T1)、体位摆放时(T2)、腰-硬联合麻醉成功后(T3)的视觉模拟评分(VAS)、数字镇静评分(NSS)、MAP及HR等的改变。结果:组内比较,对照组患者T2时的VAS评分显著高于T1(P0.05),DEZ组患者T1、T2时的VAS评分无显著差异(P0.05);对照组患者T2时的MAP、HR与T1、T3比较,均显著升高(P0.05);DEZ组患者各时点的MAP、HR无明显差异(P0.05)。组间比较,T2时DEZ组患者的VAS评分、MAP、HR均显著低于对照组,差异有统计学意义(P0.05)。结论:在下肢骨折患者行椎管内麻醉前运用地佐辛,能确切减轻体位摆放时的疼痛,不良反应发生率低,安全可行。
[Abstract]:Objective: to observe the analgesic effect of dizosin on anterior position of vertebral canal anesthesia in patients with lower extremity fracture. Methods: 80 patients with lower extremity fracture were randomly divided into two groups: dizoxin group (Dez group) and control group (n = 40). Dizosin 10 mg(2 / ml was injected intramuscularly in DEZ group and 0.9% sodium chloride was injected intramuscularly in control group. The changes of visual analogue score (VASA), digital sedation score (NSS) map and HR were recorded in two groups. Results: compared with the control group, the VAS score at T2 in the control group was significantly higher than that in the T1P 0.05 dez group. There was no significant difference in the VAS score between the T 1 and T 2 group, while in the control group, the VAS HR at T 2 and T 1 T 3 were significantly higher than those in the control group at T 2 and T 1 T 3, and there was no significant difference between the two groups at all time points (P 0.05). The VAS scores in DEZ group were significantly lower than those in the control group at T 2. The difference was statistically significant (P 0.05). Conclusion: the use of dizosin before intraspinal anesthesia in patients with fracture of lower extremity can definitely reduce the pain of posture placement, the incidence of adverse reactions is low, and it is safe and feasible.
【作者单位】：黄石市第五医院麻醉科;华中科技大学同济医学院附属同济医院麻醉科;
【基金】：国家自然科学基金资助项目(编号:81341034)
【分类号】：R614

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