全麻药物影响儿童及婴幼儿神经系统预后的研究进展

发布时间：2018-06-08 03:30

  本文选题：全麻药物 + 神经系统　； 参考：《临床麻醉学杂志》2017年12期

【摘要】：正随着外科技术进步和手术量增加,儿童及婴幼儿接受全麻的数量也不断增加,其中不乏新生儿和早产儿。发育中的大脑对全麻药物潜在的神经毒性十分敏感,早期麻醉暴露可导致神经系统递质紊乱、神经细胞凋亡变性、突触和神经突结构功能异常、神经环路无法正确形成等[1]。除一过性抑制中枢神经系统功能和神经传导外,全麻药物损伤可能进一步引起长期认知功能和行为改变[2]。以包括非人类灵长目动物在内的多个物种为对象的基础研究结果表明,
[Abstract]:The number of children and infants receiving general anesthesia, including newborns and premature infants, is increasing as surgery advances and the volume of surgery increases. The developing brain is very sensitive to the potential neurotoxicity of general anesthesia drugs. Early exposure to anesthesia may lead to neurotransmitter disorders, neuronal apoptosis, abnormal synaptic and neuronal structure and function, and the formation of neural loops. In addition to temporary inhibition of central nervous system function and nerve conduction, general anesthesia injury may further cause long-term cognitive and behavioral changes [2]. Basic research on a number of species, including non-human primates, shows that,
【作者单位】： 首都医科大学附属北京天坛医院麻醉科;
【基金】：北京市医院管理局“扬帆计划”重点医学方向(ZYLX201708) 首都卫生发展科研专项重点攻关项目(2016-1-20410)
【分类号】：R726.1
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本文编号：1994240