单叶细辛对家兔心肌的急性毒性作用

发布时间：2018-06-12 20:53

本文选题：单叶细辛 + 辽细辛　；参考：《中国老年学杂志》2015年05期

【摘要】：目的观察单叶细辛对家兔心肌急性毒性作用的影响。方法将家兔随机分为单叶细辛组、辽细辛组和生理盐水组。每组10只,分别按1 ml/kg静注1 g/ml的单叶细辛、辽细辛提取液和等量生理盐水。常规静脉麻醉,经左侧颈总动脉插管至左心室,以压力换能器连接Biolap-420E生物信号系统的血流动力学通道,心电导联线连接心电通道。全部血样均经颈静脉取血,观察并比较注射药物前后各组平均动脉压(MAP)、心输出量(CO)、心指数(CI)、左室收缩压(LVSP)、左心射血功能(LVSW)和心肌耗氧量(MVO2)、心率(HR)、心电图P-R间期、Q-T间期、缺血性T波和损伤电流,以及血清乳酸脱氢酶(LDH)、肌酸磷酸激酶(CPK)、门冬氨酸氨基转移酶(AST)、肌红蛋白(Mb)和肌钙蛋白I(CTn I)等指标的变化。结果除CI外,其余各血流动力学指标单叶细辛与辽细辛均有显著差异(P0.05),单叶细辛对ECG中ST-T的改变以及对心肌AST、CPK、CTn I等酶学指标升高的影响均高于辽细辛(P0.05)。结论单叶细辛水溶性成分对心肌细胞的毒性高于辽细辛。
[Abstract]:Objective to observe the effect of Asarum mongolicum on acute myocardial toxicity in rabbits. Methods Rabbits were randomly divided into single leaf Asarum group, Liaoxin group and normal saline group. 10 rats in each group were infused intravenously with 1 g/ml of single leaf Asarum, Liaoxin extract and the same amount of normal saline at 1 ml/kg. Under routine intravenous anesthesia, left ventricle was intubated through the left common carotid artery. The Biolap-420E biological signal system was connected with a pressure transducer and the ECG leads were connected with the ECG channel. All blood samples were collected through jugular vein. The mean arterial pressure (MAPP), cardiac output, left ventricular systolic pressure (LVSPN), left ventricular ejection function (LVSWT), myocardial oxygen consumption (MVO2), heart rate (HRT), P-R interval Q-T interval (Q-T interval) were observed and compared before and after injection of the drug. The changes of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate aminotransferase (AST), myoglobin (Mb) and troponin I (I) were observed. Results except CI, there were significant differences in the other hemodynamic indexes between Asarum and Asarum. The changes of ST-T in ECG and the increase of enzyme indexes such as myocardial ASTX CPKN I were higher than that of Asarum asarum (P 0.05). Conclusion the toxicity of water soluble components of Asarum monolayensis to cardiomyocytes is higher than that of Asarum monolayensis.
【作者单位】：甘肃中医学院生理教研室
【基金】：甘肃省教育厅科研项目(No.02B4-04)
【分类号】：R285.5

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