帕瑞昔布在瑞芬太尼全身麻醉手术中的临床效果观察

发布时间：2018-06-23 06:13

本文选题：帕瑞昔布 + 瑞芬太尼　；参考：《中外医学研究》2016年10期

【摘要】：目的:研究分析帕瑞昔布在瑞芬太尼全身麻醉手术中的临床效果,为后期的瑞芬太尼全身麻醉手术提供相应的借鉴以及参考。方法:选取2013年12月-2015年2月笔者所在医院行全身麻醉手术的患者50例作为研究对象,将其列为帕瑞昔布镇痛组,进行帕瑞昔布镇痛。同时选取同期进行全身麻醉手术的患者50例作为生理盐水镇痛组,生理盐水镇痛组进行等容量生理盐水镇痛。在完成手术后对患者的术后疼痛、围术期炎性水平等进行分析研究,对比两组患者的效果。结果:拔管后,帕瑞昔布镇痛组患者各时间段VAS疼痛评分均明显低于生理盐水镇痛组,差异均有统计学意义(P0.05);镇痛后帕瑞昔布镇痛组患者的IL-6水平、IL-8水平均明显低于生理盐水镇痛组,差异均有统计学意义(P0.05),IL-10水平明显高于生理盐水镇痛组,差异有统计学意义(P0.05);两组患者气管导管拔除前的评分比较,差异均无统计学意义(P0.05);拔管后10 min评分情况,生理盐水镇痛组躁动评分均明显高于帕瑞昔布镇痛组,镇静评分明显低于帕瑞昔布镇痛组,差异均有统计学意义(P0.05)。结论:使用帕瑞昔布可以促使瑞芬太尼全身麻醉患者的术后疼痛感受有效的降低,可以促使围术期炎症因子的水平进一步降低,说明帕瑞昔布在瑞芬太尼全身麻醉手术中具有非常显著的临床效果,值得进一步推广使用。
[Abstract]:Objective: to study the clinical effect of pareoxib in remifentanil general anesthesia, and to provide reference for remifentanil general anesthesia. Methods: 50 patients undergoing general anesthesia operation in our hospital from December 2013 to February 2015 were selected as the study objects, and they were classified as the pareoxib analgesia group for paroxib analgesia. At the same time, 50 patients undergoing general anesthesia were selected as normal saline analgesia group and saline analgesia group. The postoperative pain and perioperative inflammatory level were analyzed and compared between the two groups. Results: after extubation, the VAS pain scores of patients in the pareoxib analgesia group were significantly lower than those in the saline analgesia group. The levels of IL-6 and IL-8 in pareoxib analgesia group were significantly lower than those in saline analgesia group (P0.05), and the level of IL-10 was significantly higher than that in saline analgesia group. The difference was statistically significant (P0.05); there was no significant difference between the two groups before trachea extubation (P0.05); 10 min after extubation, the restlessness score of saline analgesia group was significantly higher than that of pareoxib analgesia group. Sedation score was significantly lower than that of pareoxib analgesia group, the difference was statistically significant (P0.05). Conclusion: the use of pareoxib can effectively reduce postoperative pain perception in patients with remifentanil general anesthesia, and further decrease the level of inflammatory factors in perioperative period. The results suggest that pareoxib has a significant clinical effect in remifentanil general anesthesia, and it is worth further popularizing.
【作者单位】：张家界市人民医院;
【分类号】：R614

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