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术中保温对老年病人全麻开腹手术苏醒时间及丙泊酚苏醒效应室浓度的影响

发布时间:2018-06-24 16:16

  本文选题:全麻 + 老年病人 ; 参考:《泸州医学院》2014年硕士论文


【摘要】:目的:研究术中保温干预在老年患者开腹手术中对苏醒期丙泊酚效应室浓度,拔管时间,以及在麻醉恢复室停留(PACU)时间的影响。方法:选择60岁以上全麻下行开腹胃肠外科手术的患者44例,ASA I~II级,随机分为实验组(C组)和对照组(N组),每组22例。两组均采用全凭静脉麻醉下手术,麻醉后使用丙泊酚2~4ug/ml和瑞芬4ng/ml持续输注术中镇静和镇痛,并间断推注顺式阿曲库铵维持肌松。术中监测心电图,血压,氧饱和度,采用脑电双频指数(BIS)监测麻醉深度,肌松监测仪监测患者肌松4个成串刺激(train of four, TOF),以腔内体温探头监测食道温度。术中实验组均输入40℃的液体,暖风毯(39℃)覆盖,腹腔冲洗液加温(40℃)。对照组常规处理。记录并比较两组患者术前(T0)麻醉诱导后30分钟(T1),60分钟(T2),90分钟(T3),120分钟(T4),150分钟(T5)术毕(T6)的体温,血压,心率,氧饱和度;记录术毕(T6),BIS恢复到80时的TOF值;记录BIS恢复到80时候TCI系统计算的丙泊酚效应室浓度(Pce),采集患者停药到BIS≥80的时间(S0),患者停药到拔管时间(S1),PACU停留时间(S2)和寒战不适的例数,分析术毕(T6)温度与丙泊酚效应室浓度(Pce),停药后BIS≥80时间(S0),患者停药到拔管时间(S1),,PACU停留时间(S2)的相关性。结果:两组患者术中的血压,心率,氧饱和度比较无统计学差异。两组患者在记录术毕(T6),BIS恢复到80时的TOF值比较无统计学差异。对照组在T2,T3,T4,T5,T6时间点的温度显著低于实验组(P<0.05)。在患者BIS恢复80时候,实验组的丙泊酚效应室浓度(Pce)明显高于对照组(P<0.05)。与对照组相比,实验组自停药到BIS回复80的时间(S0),患者拔管时间(S1)与PACU停留时间(S2)较对照组缩短(P0.05)。在PACU,实验组出现寒颤者2例,3例患者自诉感觉寒冷。对照组出现寒颤者8例,10例患者自诉感觉寒冷。术中失血实验组低于对照组,有统计学意义(P<0.05)。术毕体温与苏醒期丙泊酚效应室浓度,BIS恢复时间,拔管时间,PACU停留时间相关性显著。结论:保温干预能较好的维持老年患者术中体温,防止低体温的发生,体温对全麻老年患者的苏醒有影响。术中维持正常的体温能加快患者的苏醒,缩短拔管时间以及在PACU停留的时间,减少患者在PACU寒颤不适的发生率。
[Abstract]:Objective: to study the effects of intraoperative heat preservation intervention on the concentration of propofol effector chamber, extubation time, and stay in anaesthesia recovery chamber (PACU) during open operation in elderly patients. Methods: Forty-four patients over 60 years old undergoing open gastrointestinal surgery were randomly divided into experimental group (group C) and control group (group N) with 22 cases in each group. Both groups were treated with total intravenous anesthesia. After anesthesia, propofol 2~4ug/ml and remifen 4ng/ml were used for sedation and analgesia, and cis atracurium was used to maintain muscle relaxation. Electrocardiogram (ECG), blood pressure (BP), oxygen saturation (O _ 2) were monitored during operation, anesthesia depth was monitored by bispectral index (BIS), four strands of muscle relaxation stimulation (train of four, TOF) were monitored by muscle release monitor, and esophageal temperature was monitored by endothermic probe. The experimental group was treated with 40 鈩

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