大量失血对老年大鼠空间学习记忆能力的影响

发布时间：2018-06-27 13:11

本文选题：出血 + 记忆　；参考：《重庆医学》2015年02期

【摘要】：目的探讨大量失血对SD老年大鼠空间学习记忆能力的影响。方法将56只SD老年大鼠分为空白组(B组,n=8)、对照组(C组,n=24)和大量失血组(H组,n=24)。B组不做任何处理,C组对老年大鼠麻醉后,游离股动脉并结扎、缝合。H组对老年大鼠麻醉后,先游离股动脉然后行股动脉穿刺、放血,再行股动脉结扎、缝合。用Morris水迷宫检测3组老年大鼠不同时段的空间学习记忆能力。结果 H组术后1、3、7d的逃避潜伏期分别为:(29.93±7.93)、(34.56±6.74)、(15.47±6.42)s。与B组逃避潜伏期(12.56±3.08)s比较,H组老年大鼠的逃避潜伏期在大量失血后1、3d差异均有统计学意义(P0.05),大量失血后7d差异无统计学意义(P0.05)。C组老年大鼠在术后1、3、7d的逃避潜伏期分别为:(15.74±5.86)、(15.61±2.56)、(13.56±4.61)s,与B组逃避潜伏期(12.56±3.08)s比较,差异均无统计学意义(P0.05)。结论大量失血导致了老年大鼠空间学习记忆能力的损害。
[Abstract]:Objective to investigate the effect of massive blood loss on spatial learning and memory ability of SD aged rats. Methods Fifty-six old SD rats were divided into three groups: blank group (group B), control group (group C) and massive blood loss group (group H). The femoral artery was then punctured, bled, and then ligated and sutured. The spatial learning and memory abilities of aged rats in three groups were measured by Morris water maze. Results the escape latency of group H was (29.93 卤7.93), () 34.56 卤6.74), (15.47 卤6.42) s. Compared with group B (12.56 卤3.08) s, the escape latency of aged rats in H group was significantly different on 1 and 3 days after massive hemorrhage (P0.05), but there was no significant difference on 7 days after massive hemorrhage (P0.05). The escape latency of aged rats in group C on 1 day and 37 days after operation was similar to that in group C (P0.05). The escape latency was (15.74 卤5.86), (15.61 卤2.56), (13.56 卤4.61) s in group B and (12.56 卤3.08) s in group B, respectively. The difference was not statistically significant (P0.05). Conclusion large amount of blood loss leads to the impairment of spatial learning and memory ability in aged rats.
【作者单位】：江苏省麻醉学重点实验室;解放军第309医院麻醉科;
【基金】：总参军事医学和老年病科研基金项目(ZCWS14C20)
【分类号】：R614

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