右美托咪定用于盆腔器官脱垂老年患者盆底重建术的麻醉效果

发布时间：2018-07-11 21:41

本文选题：右美托咪定 + 老年患者　；参考：《中国药房》2015年33期

【摘要】：目的:观察右美托咪定用于盆腔器官脱垂(POP)老年患者的麻醉效果。方法:60例拟行盆底重建术的老年患者随机均分为观察组和对照组。麻醉诱导前15 min,观察组患者静脉泵注右美托咪定0.5μg/kg;对照组患者静脉泵注0.9%氯化钠注射液0.125 ml/kg,15 min后行常规静脉诱导。观察两组患者入室时(T0)、给药后5 min(T1)、插管即时(T2)、插管后1 min(T3)、插管后5min(T4)、手术切皮时(T5)、拔管即时(T6)、拔管后5 min(T7)的平均动脉压(MAP)、心率(HR)、脑电双频指数(BIS),记录躁动评分、Ramsay镇静评分、苏醒时间及不良反应发生情况。结果:观察组患者T1~7时,MAP、HR均显著低于同组T0时及对照组,对照组除T1时显著低于同组T0时外,T2~7时MAP、HR均显著高于同组T0时,差异均有统计学意义(P0.05);两组患者T1~7时BIS均显著低于同组T0时,差异均有统计学意义(P0.05),但两组间比较差异无统计学意义(P0.05)。观察组患者躁动评分显著低于对照组,Ramsay镇静评分显著高于对照组,差异均有统计学意义(P0.05);两组患者苏醒时间比较,差异无统计学意义(P0.05)。两组患者用药期间均未见明显不良反应发生。结论:右旋美托咪啶用于盆底重建术老年患者,可有效降低患者应激反应,维持循环稳定,安全性较好。
[Abstract]:Objective: to observe the anesthetic effect of dexmetomidine in elderly patients with pelvic organ prolapse (pop). Methods 60 elderly patients undergoing pelvic floor reconstruction were randomly divided into observation group and control group. Before anesthesia induction, the patients in the observation group were injected with dexmetomidine 0.5 渭 g / kg by intravenous pump, and the patients in the control group were injected with 0.9% sodium chloride injection 0.125 ml / kg for 15 min after routine intravenous induction. The mean arterial pressure (map), heart rate (HR) and bispectral index (HR) of 5 min (T7), 5 min (T1), 1 min (T3), 1 min (T3), T4, T5, T6, 5 min after extubation were observed in both groups. Recovery time and adverse reactions. Results: the T1-7 MAPHR in the observation group was significantly lower than that in the same group and the control group, and the MAPHR in the control group except T1 was significantly lower than that in the same group at T0, and the MAPHR in T2-7 in the control group was significantly higher than that in the same group at T0. The difference was statistically significant (P0.05); the BIS of the two groups were significantly lower than that of the same group T0 (P0.05), but there was no significant difference between the two groups (P0.05). The restlessness score of observation group was significantly lower than that of control group Ramsay sedation score was significantly higher than that of control group, the difference was statistically significant (P0.05); there was no significant difference in recovery time between two groups (P0.05). There were no obvious adverse reactions in both groups. Conclusion: dexmetidine for pelvic floor reconstruction in elderly patients can effectively reduce stress response, maintain stable circulation and good safety.
【作者单位】：南京医科大学附属南京妇幼保健院麻醉科;
【分类号】：R614

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