七氟烷和丙泊酚麻醉对老年肺癌患者术后认知功能的影响

发布时间：2018-07-12 11:27

本文选题：七氟烷 + 丙泊酚　；参考：《中国实用医药》2014年07期

【摘要】：目的探讨七氟烷和丙泊酚麻醉对老年肺癌患者术后认知功能的影响。方法回顾性分析2010年1月~2013年12月本院收治的106例老年肺癌患者的临床资料,随机将所有患者分为观察组和对照组,每组各53例,分别于术前12 h,术后6 h、12 h、1 d、3 d、7 d对两组的患者进行MMSE评分,麻醉前、术后及术后1 d取静脉血测定血清中的S100β蛋白浓度浓度。结果所有患者均顺利完成手术,术中的各生命体征平稳,两组患者的者年龄、体重、疾病构成等差异无统计学意义(P0.05),术前MMSE评分及术前S100β蛋白差异无统计学意义(P0.05)。术后两组的MMSE评分差异有统计学意义(P0.05)。结论七氟烷与丙泊酚均可提高老年患者全身麻醉术后早期认知功能。但七氟烷与丙泊酚相比,术后认知功能障碍的发生率较低,恢复更快。
[Abstract]:Objective to investigate the effect of sevoflurane and propofol anesthesia on postoperative cognitive function in elderly patients with lung cancer. Methods the clinical data of 106 elderly patients with lung cancer treated in our hospital from January 2010 to December 2013 were analyzed retrospectively. All patients were randomly divided into observation group and control group with 53 cases in each group. The MMSE scores were evaluated at 12 hours before operation and 6 hours after operation. The serum S100 尾 protein levels were measured before anesthesia, after operation and 1 day after operation. Results all the patients completed the operation successfully. The vital signs of the two groups were stable. There was no significant difference in age, body weight and disease composition between the two groups (P0.05), but there was no significant difference in preoperative MMSE score and S100 尾 protein between the two groups (P0.05). There was significant difference in MMSE score between the two groups after operation (P0.05). Conclusion both sevoflurane and propofol can improve the early cognitive function of elderly patients after general anesthesia. However, sevoflurane has a lower incidence of postoperative cognitive impairment and faster recovery than propofol.
【作者单位】：山东省烟台市莱阳中心医院麻醉科;
【分类号】：R614

【参考文献】