舒芬太尼复合丙泊酚在经阴道超声取卵术中的应用研究

发布时间：2018-07-21 08:58

【摘要】：目的:观察舒芬太尼联合丙泊酚静脉麻醉在经阴道超声取卵术中的安全性及临床效果。方法:选取实施体外受精-胚胎移植术拟行经阴道超声无痛取卵术的育龄期妇女100例,随机分为舒芬太尼复合丙泊酚组(S组)和芬太尼复合丙泊酚组(F组)。入室监护生命体征后,S组静脉注射舒芬太尼5μg,F组静脉注射芬太尼50μg,消毒铺巾后,两组患者均缓慢静脉注射丙泊酚70~75 mg。术中保持患者呼吸道通畅,有体动或睁眼反应时追加丙泊酚10~20mg。观察并记录两组患者术前(静脉注射丙泊酚前)、术中(手术开始后3 min)的平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(Sp O2);记录手术时间、麻醉苏醒时间(静脉注射丙泊酚至意识恢复时间)、术中呼吸抑制、身体扭动、术后恶心、呕吐、眩晕的发生情况。结果:两组患者一般资料、手术时间、麻醉苏醒时间比较,差异无统计学意义;两组患者的丙泊酚用量比较,S组明显减少,差异有统计学意义(P0.05);与术前相比,两组患者术中的MAP和HR明显降低,但均在正常生理范围内,Sp O2无显著变化;两组患者术中呼吸抑制、术后恶心、呕吐、眩晕等发生情况比较,差异无统计学意义。S组患者体动比F组显著减少(P0.05)。结论:舒芬太尼复合丙泊酚能有效减少经阴道超声取卵术中患者体动次数,减少丙泊酚的用量,安全有效,麻醉效果好。
[Abstract]:Objective: to observe the safety and clinical effect of sufentanil combined with propofol intravenous anesthesia in transvaginal ultrasound. Methods: 100 women of childbearing age undergoing in vitro fertilization and embryo transfer were randomly divided into sufentanil combined propofol group (S group) and fentanyl combined propofol group (F group). After vital signs were monitored, sufentanil was injected intravenously into group S (5 渭 g) and fentanyl (50 渭 g) was injected intravenously in group F. After disinfecting and spreading towel, propofol 705mg was injected slowly into both groups. During operation, the respiratory tract was patency and propofol was added to 20 mg / g of propofol when there was body movement or eye opening reaction. The mean arterial pressure (map), heart rate (HR), pulse oxygen saturation (SPO _ 2) were observed and recorded before operation (before intravenous injection of propofol), during operation (3 min after operation), and the time of operation was recorded, and the mean arterial pressure (map), heart rate (HR) and pulse oxygen saturation (SPO _ 2) were recorded. Anaesthesia recovery time (intravenous injection of propofol to consciousness recovery time), intraoperative respiratory inhibition, body torsion, postoperative nausea, vomiting, vertigo occurrence. Results: there was no significant difference in general data, operation time and anaesthesia recovery time between the two groups. The dosage of propofol in the two groups was significantly reduced compared with that in group S (P0.05); compared with pre-operation, the dosage of propofol in two groups was significantly lower than that in group S (P0.05). Map and HR decreased significantly in both groups, but there was no significant change in SPO _ 2 in normal physiological range, the incidence of respiratory depression, postoperative nausea, vomiting and vertigo were compared between the two groups. There was no significant difference between group S and group F (P0.05). Conclusion: sufentanil combined with propofol can effectively reduce the number of body movements and the dosage of propofol during transvaginal ultrasound oocyte extraction.
【作者单位】：山西省儿童医院山西省妇幼保健院;
【分类号】：R614

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