盐酸羟考酮复合丙泊酚静脉麻醉用于无痛肠镜的临床观察

发布时间：2018-07-21 14:17

【摘要】：目的探讨盐酸羟考酮注射液复合丙泊酚静脉麻醉用于无痛肠镜检查的临床有效安全性。方法 100例ASA I-III级年龄18-70岁择期行无痛肠镜检查的患者,按照随机数字表分为对照组(C组),羟考酮组(O组),每组均50例。C组术前10min静脉注射盐酸羟考酮注射液0.1mg/kg,B组术前十分钟静脉注射芬太尼注射液1ug/kg。术中麻醉均使用1.5-3mg/kg丙泊酚,睫毛反射消失开始行肠镜检查。观察并记录患者肠镜检查过程中基本生命体征HR、SBP、SPO2的连续动态变化和患者检查过程及苏醒后24h内不良事件(呛咳、呼吸抑制,恶心呕吐,腹痛腹胀,术后躁动),术毕VAS评分和丙泊酚用量。结果 C组患者HR、SBP、SPO2与O组比较无显著差异性(P0.05)。O组术毕VAS评分明显低于C组(P0.05)。C组异丙酚使用剂量及不良事件发生率均明显高于O组,差异具有统计学意义(P0.05)。结论盐酸羟考酮复合丙泊酚静脉麻醉用于无痛电子肠镜检查术,术中循环稳定,术后不良事件发生明显降低,安全性好。
[Abstract]:Objective to investigate the clinical efficacy and safety of hydroxycodone hydrochloride injection combined with propofol intravenous anesthesia for painless enteroscopy. Methods 100 ASA I-III patients aged 18-70 years underwent painless endoscopy. According to the random number table, each group was divided into two groups: control group (group C) and hydroxycodone group (group O). Each group was treated with 10min injection of 0.1 mg 路kg ~ (-1) 路min ~ (-1) 路min before operation. 1.5-3mg/kg propofol was used during anesthesia, and eyelash reflex disappeared. To observe and record the continuous dynamic changes of the basic vital signs of HRN SBP and SPO 2 during endoscopy, and the adverse events (cough, respiratory inhibition, nausea and vomiting, abdominal pain and abdominal distension) within 24 hours after recovery. Postoperative restlessness), postoperative VAS score and propofol dosage. Results there was no significant difference between group C and O (P0.05). The VAS score of group O was significantly lower than that of group C (P0.05). The incidence of adverse events of propofol in group C (P0.05) was significantly higher than that in group O (P0.05). Conclusion intravenous anesthesia with hydroxycodone hydrochloride combined with propofol is safe and safe for painless enteroscopy.
【作者单位】：江西省南昌县人民医院麻醉科;
【分类号】：R614

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