芬太尼复合氟比洛芬酯对乳腺癌根治术患者术后疼痛的影响
发布时间：2018-07-31 05:42
【摘要】：目的：探讨术中静脉注射芬太尼复合氟比洛芬酯对乳腺癌根治术患者术后疼痛的影响。 方法：采用随机、双盲、对照的研究方法,将60例行乳腺癌根治术的患者分成3组：芬太尼组(F组)、芬太尼复合氟比洛芬酯组(KF组)和对照组(N组),每组20例。所有患者均采用气管内插管全身麻醉。在常规麻醉的基础上,F组患者切皮后45min静脉注射芬太尼2.0μg/kg；KF组患者切皮前10min和手术结束即刻分别予氟比洛芬酯1mg/kg,并于切皮后45min静注芬太尼2.0μg/kg；N组患者不做特殊处理。用疼痛视觉模拟评分法(VAS评分)双盲评估患者术后拔管即刻、3h、6h、12h、第1天、第2天、第3天、第7天的疼痛程度,观察术后48h内其他镇痛药的使用情况以及术后恶心呕吐、呼吸抑制等相关的不良反应的发生率。 结果：三组患者年龄、身高、体重、临床病理特征等情况的比较差异无统计学意义(P0.05)。KF组患者术后拔管即刻、3h、6h、12h、第1天、第2天的VAS评分均比F组和N组患者低(P0.05)；F组患者术后拔管即刻VAS评分低于N组(P0.05),而术后3h、6h、12h、第1天、第2天F组和N组患者VAS评分比较差异无统计学意义(P0.05)；术后第3天、第7天三组患者的VAS评分比较,差异无统计学意义(P0.05)；三组患者术后48h镇痛药用量以及不良反应发生率的比较,差异无统计学意义(P0.05)。 结论：术中静脉注射芬太尼复合氟比洛芬酯可减轻乳腺癌根治术患者的术后早期疼痛,且不增加不良反应的发生率。
[Abstract]:Objective: to investigate the effect of intraoperative intravenous fentanyl combined with flurbiprofen ester on postoperative pain in patients with breast cancer. Methods: 60 patients undergoing radical mastectomy were randomly divided into three groups: fentanyl group (group F), fentanyl combined with flurbiprofen group (group KF) and control group (group N). All patients were anesthetized by endotracheal intubation. On the basis of routine anesthesia, the patients in group F were given flurbiprofen 1 mg / kg before skin incision and immediately after operation by intravenous 45min injection of fentanyl 2.0 渭 g / kg 路kg ~ (-1) after skin incision, and the patients in group N received intravenous fentanyl 2.0 渭 g 路kg ~ (-1) / kg of fentanyl intravenously after incision, and no special treatment was given to the patients in the group of Fentanyl 2.0 渭 g / kg of fentanyl. Pain visual analogue score (VAS) was used to evaluate the degree of pain in patients with postoperative pain after extubation for 6 h or 12 h, day 1, day 2, day 3, day 7, and to observe the use of other analgesics within 48 hours after operation and postoperative nausea and vomiting. Incidence of related adverse reactions such as respiratory suppression. Results: there was no significant difference in age, height, weight and clinicopathological features among the three groups (P0.05). The VAS scores of the patients in KF group were lower than those in group F and group N (P0.05). The VAS score of group F was lower than that of group N immediately after extubation (P0.05), but there was no significant difference in VAS score between group F and group N on day 1, day 2, day 1, day 2 (P0.05), VAS score of group 3 and day 7 after operation was higher than that of group N (P0.05). The difference was not statistically significant (P0.05); there was no significant difference between the three groups in the dosage of analgesics and the incidence of adverse reactions 48 hours after operation (P0.05). Conclusion: intraoperative intravenous injection of fentanyl combined with flurbiprofen ester can relieve early postoperative pain in patients with breast cancer, and does not increase the incidence of adverse reactions.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R614
本文编号：2154602
[Abstract]:Objective: to investigate the effect of intraoperative intravenous fentanyl combined with flurbiprofen ester on postoperative pain in patients with breast cancer. Methods: 60 patients undergoing radical mastectomy were randomly divided into three groups: fentanyl group (group F), fentanyl combined with flurbiprofen group (group KF) and control group (group N). All patients were anesthetized by endotracheal intubation. On the basis of routine anesthesia, the patients in group F were given flurbiprofen 1 mg / kg before skin incision and immediately after operation by intravenous 45min injection of fentanyl 2.0 渭 g / kg 路kg ~ (-1) after skin incision, and the patients in group N received intravenous fentanyl 2.0 渭 g 路kg ~ (-1) / kg of fentanyl intravenously after incision, and no special treatment was given to the patients in the group of Fentanyl 2.0 渭 g / kg of fentanyl. Pain visual analogue score (VAS) was used to evaluate the degree of pain in patients with postoperative pain after extubation for 6 h or 12 h, day 1, day 2, day 3, day 7, and to observe the use of other analgesics within 48 hours after operation and postoperative nausea and vomiting. Incidence of related adverse reactions such as respiratory suppression. Results: there was no significant difference in age, height, weight and clinicopathological features among the three groups (P0.05). The VAS scores of the patients in KF group were lower than those in group F and group N (P0.05). The VAS score of group F was lower than that of group N immediately after extubation (P0.05), but there was no significant difference in VAS score between group F and group N on day 1, day 2, day 1, day 2 (P0.05), VAS score of group 3 and day 7 after operation was higher than that of group N (P0.05). The difference was not statistically significant (P0.05); there was no significant difference between the three groups in the dosage of analgesics and the incidence of adverse reactions 48 hours after operation (P0.05). Conclusion: intraoperative intravenous injection of fentanyl combined with flurbiprofen ester can relieve early postoperative pain in patients with breast cancer, and does not increase the incidence of adverse reactions.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R614
【参考文献】
相关期刊论文 前10条
1 陈华军;拾翠翠;周静;;氟比洛芬酯超前镇痛对围术期应激反应及术后镇痛效果的影响[J];重庆医学;2010年20期
2 许学兵;宋文涛;;小剂量右美托咪定复合曲马多用于改良乳腺癌根治术后病人自控静脉镇痛的临床效果[J];广东医学;2012年17期
3 王琰;;氟比洛芬酯复合舒芬太尼用于全身麻醉术后镇痛[J];临床医学;2013年01期
4 佘守章;许学兵;;超前镇痛有效性争议及预防性镇痛的研究新进展[J];临床麻醉学杂志;2008年06期
5 陈雄刚;陈百红;林财珠;;氟比洛芬酯在大鼠手术切口组织中靶向分布的研究[J];临床麻醉学杂志;2009年05期
6 徐建国;;成人术后疼痛治疗进展[J];临床麻醉学杂志;2011年03期
7 王晓山;刘沛;王东信;李世忠;丁婷;贾茜茜;;氟比洛芬酯复合舒芬太尼镇痛对骨科患者术后谵妄发生率的影响[J];临床麻醉学杂志;2012年02期
8 高玉洁;;非甾体抗炎药物的临床应用及安全性评价[J];实用药物与临床;2009年02期
9 王小慧;王俊;;阿片类药物诱导痛觉过敏的研究进展[J];实用药物与临床;2011年05期
10 万梅方;辜晓岚;鲁振;顾连兵;;不同时间点应用氟比洛芬酯对食管癌患者术后静脉自控镇痛效果的影响[J];中华实用诊断与治疗杂志;2013年02期
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