患儿支气管异物手术麻醉中芬太尼血药浓度分析
发布时间:2018-08-13 13:38
【摘要】:目的比较丙泊酚TCI复合不同剂量芬太尼行患儿支气管异物取出术的麻醉效果,并寻找适宜的芬太尼血药浓度。方法选择急诊行支气管异物取出术患儿200例,男107例,女93例,年龄8个月~2岁,体重8.3~12.0kg,ASAⅡ或Ⅲ级,随机分为四组:芬太尼1μg/kg组(A组)、芬太尼1.5μg/kg组(B组)、芬太尼2μg/kg组(C组)和芬太尼2.5μg/kg组(D组),每组50例。均复合丙泊酚TCI 4μg/ml,记录给药后5min硬支气管镜一次性置入的成功例数和呼吸抑制情况,并采集此时患儿的动脉血,测定芬太尼的血药浓度。结果 C组患儿麻醉效果理想,硬支气管镜一次性置入成功率(96%)明显高于A组(20%)和B组(36%),呼吸抑制发生率(8%)明显低于D组(36%)。C组血液中芬太尼有效靶浓度是(0.62±0.23)μg/L。结论芬太尼2μg/kg复合靶控输注丙泊酚4μg/ml用于患儿支气管异物取出术麻醉较平稳,血浆中芬太尼的血药浓度是(0.62±0.23)μg/L。
[Abstract]:Objective to compare the anesthetic effects of propofol TCI combined with different doses of fentanyl in bronchial foreign body removal in children and to find the appropriate concentration of fentanyl in blood. Methods 200 children (107 males and 93 females) with acute bronchial foreign body removal, aged 8 months or 2 years, weighing 8.3 ~ 12.0 kg / kg, were selected for ASA 鈪,
本文编号:2181157
[Abstract]:Objective to compare the anesthetic effects of propofol TCI combined with different doses of fentanyl in bronchial foreign body removal in children and to find the appropriate concentration of fentanyl in blood. Methods 200 children (107 males and 93 females) with acute bronchial foreign body removal, aged 8 months or 2 years, weighing 8.3 ~ 12.0 kg / kg, were selected for ASA 鈪,
本文编号:2181157
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