七氟醚联合瑞芬太尼用于产科全身麻醉对炎性细胞因子的影响

发布时间：2018-08-13 17:41

【摘要】：目的:不同全身麻醉方案应用于剖宫产手术,通过监测产妇血浆中炎性细胞因子浓度来评估应激反应的变化。方法:60例产妇随机分为七氟醚组(S组)与异丙酚组(P组),每组30例。记录产妇各时点的血流动力学数值、血中炎性细胞因子浓度、术中情况及新生儿情况。结果:P组麻醉诱导后、胎儿娩出时平均动脉压、心率与麻醉诱导前比较,差异有统计学意义(P0.05),与S组同时点比较,差异有统计学意义(P0.05)。P组术毕时及术后24 h的IL-6、TNF-α浓度比较,差异有统计学意义(P0.05);与S组同时点比较,差异有统计学意义(P0.05);P组术毕及术后24 h的s TNFRⅡ浓度比较,差异有统计学意义(P0.05);与S组同时点比较,差异有统计学意义(P0.05)。结论 :七氟醚联合瑞芬太尼的剖宫产全身麻醉方案,安全有效,能抑制应激反应,有效预防术中显性记忆的发生。
[Abstract]:Aim: to evaluate the changes of stress response by monitoring the plasma levels of inflammatory cytokines during cesarean section under different general anesthesia protocols. Methods Sixty puerperas were randomly divided into sevoflurane group (S group) and propofol group (P group) with 30 cases in each group. The hemodynamic values, the concentration of inflammatory cytokines, intraoperative and neonatal conditions were recorded. Results after anesthesia induction, the mean arterial pressure and heart rate were significantly different between the two groups (P0.05), and the concentration of IL-6TNF- 伪 in group P was significantly higher than that in group S at the end of operation and 24 hours after anesthesia induction (P0.05). The difference was statistically significant (P0.05); compared with the S group at the same time, the difference was statistically significant (P0.05), the difference was statistically significant (P0.05), the difference was statistically significant (P0.05); compared with the S group at the same time, the difference was statistically significant (P0.05). Conclusion: sevoflurane combined with remifentanil is safe and effective in general anesthesia for cesarean section.
【作者单位】：广东省妇幼保健院麻醉科;广东省妇幼保健院妇科;
【基金】：广东省医学科研基金项目(编号:A2014104)
【分类号】：R614

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