不同年龄患者意识消失时丙泊酚的用量

发布时间：2018-08-14 14:24

【摘要】：目的观察患者麻醉诱导意识消失时丙泊酚用量及Narcotrend指数(NI)变化,探讨意识消失时年龄与丙泊酚用量和NI的相关性。方法 3~70岁择期手术患者140例,按年龄分为7组,3~10岁组(G1组)、11~20岁组(G2组)、21~30岁组(G3组)、31~40岁组(G4组)、41~50岁组(G5组)、51~60岁组(G6组)及61~70岁组(G7组),每组纳入BMI在正常范围内的男女患者各10例。静脉持续输注丙泊酚20mg·kg-1·h-1至患者意识消失时停药,记录患者丙泊酚用量、意识消失时间及用药前后MAP、HR、NI的变化。结果患者意识消失时G1组丙泊酚用量明显高于G2~G7组(P0.01),G2~G4组明显高于G6、G7组(P0.05)。患者意识消失时丙泊酚用量与年龄呈显著负相关(r=-0.566,P0.001)。意识消失时间随年龄的增长而缩短。与输注丙泊酚前比较,七组患者意识消失时MAP和NI均明显降低(P0.05)。G1组NI明显高于G2~G6组(P0.05)。年龄与NI无明显相关性(r=-0.082,P=0.289)。结论麻醉诱导意识消失时不同年龄患者丙泊酚用量和NI不同,年幼患者丙泊酚用量和NI高于其他年龄患者。
[Abstract]:Objective to observe the changes of propofol dosage and Narcotrend index (NI) in patients with anaesthesia induced consciousness loss, and to explore the correlation between age and propofol dosage and NI. Methods 140 patients aged 370 years with elective surgery were studied. According to the age, the patients were divided into 7 groups: group G _ 1, group G _ 2, group G _ 3, group C _ 3, group C _ 4, group G _ 4, group C _ 5, group G _ 5, age 60 (group G _ 6) and group G _ 7 (group G _ 7). Each group included 10 male and female patients with BMI within normal range. The dosage of propofol, the time of consciousness disappearance and the changes of HRNI were recorded before and after intravenous infusion of propofol 20mg kg-1 h-1. Results the dosage of propofol in G1 group was significantly higher than that in G2~G7 group (P0.01) and G2G4 group was significantly higher than that in G6 G7 group (P0.05). The dosage of propofol was negatively correlated with age when consciousness disappeared (r = -0.566, P 0.001). The time of loss of consciousness decreases with age. Compared with those before propofol infusion, MAP and NI decreased significantly in the seven groups when consciousness disappeared (P0.05). NI in G1 group was significantly higher than that in G2~G6 group (P0.05). There was no significant correlation between age and NI (r = 0.082, P = 0.289). Conclusion the dosage of propofol and NI are different in patients with different ages when the consciousness of anesthesia induction disappears. The dosage and NI of propofol in young patients are higher than those in other ages.
【作者单位】：宁夏医科大学;宁夏医科大学总医院麻醉科;
【基金】：宁夏自然科学基金(编号:NZ1237)
【分类号】：R614

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