地佐辛联合右美托咪定预防瑞芬太尼复合麻醉患者术后痛觉过敏的临床研究

发布时间：2018-08-23 12:45

【摘要】：目的:探讨地佐辛联合右美托咪定预防瑞芬太尼复合麻醉后患者术后痛觉过敏的临床作用。方法:将62例手术患者分为对照组和观察组。对照组患者30例行瑞芬太尼复合麻醉,观察组患者32例在瑞芬太尼复合麻醉基础上给予地佐辛联合右美托咪定。评估两组患者的苏醒时间、拔管时间、疼痛程度、吗啡累积使用量及术后24 h内不良反应发生情况。结果:两组患者苏醒时间和拔管时间结果提示无统计学差异。与对照组比较,观察组患者的VAS评分明显降低,吗啡累积使用量及使用率明显减少(P0.05)。两组患者术后24 h内无呼吸抑制发生,与对照组相比,观察组患者恶心呕吐及寒颤的发生率明显降低(P0.05)。结论:地佐辛联合右美托咪定能够从不同通路降低瑞芬太尼复合麻醉引起的患者术后痛觉过敏反应。
[Abstract]:Objective:To investigate the clinical effect of dexmedetomidine combined with dextro-zocine in preventing postoperative hyperalgesia in patients undergoing remifentanil combined anesthesia.Methods:62 patients were divided into control group and observation group.30 patients in control group were given remifentanil combined anesthesia.32 patients in observation group were given dextro-zocine combined with dextro on the basis of remifentanil combined anesthesia. METOMIDINE. The recovery time, extubation time, pain degree, cumulative morphine use and adverse reactions within 24 hours were evaluated. Results: There was no significant difference between the two groups in recovery time and extubation time. The incidence of nausea, vomiting and chills in the observation group was significantly lower than that in the control group (P 0.05). Conclusion: Dezocine combined with dexmedetomidine can reduce postoperative hyperalgesia induced by remifentanil anesthesia through different pathways.
【作者单位】：沈阳美德因妇儿医院;
【分类号】：R614.1

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