电针刺激对糖尿病患者术后认知功能及血清炎性因子的影响

发布时间：2018-09-03 07:41

【摘要】：目的探讨电针刺激对糖尿病患者术后认知功能及血清炎性因子的影响。方法选择行胃肠道恶性肿瘤根治术的糖尿病患者90例,随机均分为电针刺激组(E组)和对照组(C组),另外选取45例非糖尿病患者为正常组(N组),记录三组患者麻醉前1d、术后3、7d简易智力状态评分(MMSE评分)和术后拔管及送离苏醒室的时间,于电针刺激前(T1)、手术开始后2h(T2)、手术结束后1h(T3)、术后24h(T4)抽血测患者血糖水平及血清炎性因子IL-6、IL-1β的水平,术后3、7d术后认知功能障碍(POCD)发生率。结果与C组比较,T2~T4时E组血糖、血清IL-6、IL-1β水平明显降低(P0.05)。与N组比较,T2~T4时E组、C组血糖、血清IL-6、IL-1β水平明显升高(P0.05)。与T1时比较,T2、T3时三组患者血糖、血清IL-6、IL-1β,T4时E组、C组血清IL-6、IL-1β水平明显升高(P0.05)。与T2时比较,T3时三组血糖、IL-6、IL-1β水平明显升高(P0.05),T4时三组血糖、血清IL-6、IL-1β水平明显降低(P0.05)。与T3时比较,T4时三组血糖、血清IL-6、IL-1β水平明显降低(P0.05)。术后3、7dE组和C组MMSE评分明显低于术前,术后3dE组,术后3、7dN组MMSE评分明显高于,POCD发生率明显低于C组(P0.05)。结论电针刺激可以降低糖尿病患者术后认知功能障碍的发生,并降低血清IL-6、IL-1β水平。
[Abstract]:Objective to investigate the effect of electroacupuncture stimulation on postoperative cognitive function and serum inflammatory factors in diabetic patients. Methods 90 patients with diabetes underwent radical resection of gastrointestinal malignant tumor were selected. They were randomly divided into two groups: electroacupuncture group (group E) and control group (group C). Another 45 cases of non-diabetic patients were selected as normal group (group N). The scores of simple mental state (MMSE) and extubation were recorded 1 day before anesthesia, 3 days after anesthesia and 3 days after operation. The time to be sent away from the waking room, Blood glucose levels and serum inflammatory factor IL-6,IL-1 尾 levels were measured before electroacupuncture stimulation (T1), 2 hours after operation (T2), 1 hour after operation (T3), 24 hours after operation (T4), and the incidence of (POCD) in patients with cognitive impairment at 3 and 7 days after operation. Results compared with group C, blood glucose and serum IL-6,IL-1 尾 levels in group E were significantly lower than those in group C (P 0.05). Compared with group N, blood glucose and serum IL-6,IL-1 尾 levels in group E were significantly higher than those in group B (P 0.05). The level of serum IL-6,IL-1 尾 in group E was significantly higher than that in group C at T _ 1 and T _ 2 / T _ 3 (P 0.05), and the level of serum IL-6,IL-1 尾 in group E was significantly higher than that in group E at T _ (2) T _ (3) (P < 0.05). Compared with T2, the levels of IL-6 and IL-1 尾 in the three groups were significantly higher than those in the control group (P0.05), and the serum IL-6,IL-1 尾 level was significantly lower in the three groups than in the T4 group (P0.05). Compared with T 3, the blood glucose and serum IL-6,IL-1 尾 levels in the three groups were significantly lower than those at T 4 (P 0.05). The MMSE scores in group E and group C were significantly lower than those in group C at 3 ~ 7 days after operation. The MMSE score in group N was significantly higher than that in group C at 3 ~ 7 days after operation (P0.05). Conclusion electroacupuncture stimulation can reduce the incidence of cognitive dysfunction and the level of serum IL-6,IL-1 尾 in diabetic patients.
【作者单位】：南昌大学第二附属医院麻醉科;
【基金】：江西省卫生厅中医处课题项目(2013A192)
【分类号】：R614

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