昂丹司琼对腰-硬联合麻醉剖宫产术中麻醉效果的影响

发布时间：2018-09-05 20:45

【摘要】：目的:观察昂丹司琼对腰-硬联合麻醉剖宫产术中麻醉效果的影响。方法:60例单胎足月产妇随机均分为试验组和对照组。试验组产妇于麻醉前30 min静脉输注6%羟乙基淀粉(130/0.4)电解质注射液500 ml,麻醉前5 min给予盐酸昂丹司琼注射液4 ml,缓慢静脉推注;对照组产妇于麻醉前30 min静脉输注6%羟乙基淀粉(130/0.4)电解质注射液500 ml,麻醉前5 min给予0.9%氯化钠注射液4 ml缓慢静脉推注。记录两组产妇开始实施麻醉穿刺前(T1)、麻醉后产妇取左侧卧位后(T2)、胎儿娩出后(T3)、手术结束时(T4)的平均动脉压(MAP)、心率(HR),新生儿Apgar评分及不良反应发生情况。结果:对照组产妇T2、T3时点MAP显著低于同组T1时点及试验组,HR显著高于同组T1时点及试验组,差异均有统计学意义(P0.05);试验组产妇各时点MAP、HR比较,差异均无统计学意义(P0.05)。试验组新生儿出生后1 min Apgar评分显著高于对照组,差异有统计学意义(P0.05),两组新生儿出生后5 min Apgar评分比较,差异无统计学意义(P0.05)。试验组产妇不良反应发生率显著低于对照组,差异有统计学意义(P0.05)。结论:腰-硬联合麻醉剖宫产手术中应用昂丹司琼后,可有效降低恶心呕吐、低血压的发生,安全性较好。
[Abstract]:Objective: to observe the effect of ondansetron on epidural anesthesia during cesarean section. Methods 60 single term parturient women were randomly divided into trial group and control group. In the test group, intravenous infusion of 6% hydroxyethyl starch (130 / 0.4) electrolyte injection 5 ml, before anesthesia was given to ondansetron hydrochloride injection 4 ml, slowly intravenously at 30 min before anesthesia. In the control group, 6% hydroxyethyl starch (130 / 0.4) electrolyte injection was injected intravenously 30 min before anesthesia (500 ml,) and 0.9% sodium chloride injection (4 ml) was given slowly intravenously 5 min before anesthesia. The mean arterial pressure (MAP),) heart rate (HR),) Apgar score and adverse reaction were recorded before anesthesia (T1), after left lying position (T2), after fetal delivery (T3), and at the end of operation (T4). Results: the MAP of the control group at T 2T 3 time point was significantly lower than that of the control group at T 1 time point and the HR of the test group was significantly higher than that of the same group T 1 time point and the test group (P0.05), while the MAP,HR of the test group at each time point had no statistical significance (P0.05). The min Apgar score of the newborns in the trial group was significantly higher than that in the control group (P0.05), and there was no significant difference between the two groups in 5 min Apgar postnatal score (P0.05). The incidence of adverse reactions in the trial group was significantly lower than that in the control group (P0.05). Conclusion: Ondansetron can effectively reduce nausea and vomiting, hypotension and safety after combined spinal-epidural anesthesia in cesarean section.
【作者单位】：浙江洞头县人民医院麻醉科;
【分类号】：R614.4

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