全身麻醉时罗库溴铵的肌肉松弛作用与患者体质量指数的关系

发布时间：2018-09-13 12:57

【摘要】：目的研究全身麻醉时罗库溴铵的肌肉松弛(以下简称肌松)效果及其与患者BMI的关系。方法选择2012年7月至2013年7月该院86例手术时接受全身麻醉的患者。随机分成体质量适中组(28例)、高体质量组(28例)和低体质量组(30例),3组均在5s内静脉注射罗库溴铵,记录并对比各组起效时间、无反应期及恢复指数情况,并比较各组间药效及用药剂量。结果高体质量组起效时间显著短于低体质量组和体质量适中组;体质量适中组显著短于低体质量组。高体质量组无反应期显著长于体质量适中组及低体质量组,体质量适中组显著长于低体质量组,差异均有统计学意义(均P0.05)。各组的恢复指数差异无统计学意义(均P0.05)。高体质量组药理作用时间及肌松药用量均显著大于体质量适中及低体质量组,体质量适中组显著大于低体质量组,差异均有统计学意义(均P0.05)。结论当按BMI进行静脉注射罗库溴铵,高体质量组起效时间最短,无反应期最长,但恢复指数与患者体质量无明显相关性。
[Abstract]:Objective To study the effect of rocuronium on muscle relaxation during general anesthesia and its relationship with BMI. Methods From July 2012 to July 2013, 86 patients undergoing general anesthesia were randomly divided into moderate weight group (28 cases), high weight group (28 cases) and low weight group (30 cases). Results The onset time of high body mass group was significantly shorter than that of low body mass group and moderate body mass group, and the moderate body mass group was significantly shorter than that of low body mass group. There was no significant difference in recovery index between the two groups (all P 0.05). The time of pharmacological action and the dosage of muscle relaxants in the high body mass group were significantly longer than those in the moderate body mass group and the low body mass group. Conclusion When intravenous rocuronium was administered according to BMI, the onset time of rocuronium was the shortest and the non-response time was the longest in the high body mass group, but the recovery index was not significantly correlated with the patient's body mass.
【作者单位】：海南省儋州市农垦那大医院麻醉科;
【分类号】：R614

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