右美托咪定在超声引导下经皮射频消融治疗肝肿瘤的临床应用

发布时间：2018-09-14 16:26

【摘要】：目的:探讨右美托咪定应用于超声引导下经皮射频消融治疗肝肿瘤的可行性。方法:将40例行超声引导下经皮射频消融治疗肝肿瘤的患者随机分成D组和L组,每组20例。D组患者于术前10 min持续输注右美托咪定0.5μg(/kg·h),患者意识消失后开始手术;L组患者在术前10 min输注乳酸林格液的同时给予咪达唑仑0.05 mg/kg。两组患者均采用0.5%利多卡因局部麻醉,术中常规面罩给氧3~4 L/min。观察不同时点的心率(HR)、平均动脉压(MAP)、血氧饱和度(Sp O2)、镇静和疼痛评分。结果:两组患者给药前的HR、MAP、Sp O2差异无统计学意义(P0.05),操作开始后L组出现心率和血压升高(P0.05);D组的镇静评分和镇痛效果明显优于L组(P0.05),Sp O2差异无统计学意义(P0.05)。结论:该研究中,右美托咪定用于超声引导下经皮射频消融治疗肝肿瘤是安全、有效的。
[Abstract]:Objective:To investigate the feasibility of percutaneous radiofrequency ablation of liver tumors with dexmedetomidine guided by ultrasound.Methods:Forty patients with liver tumors were randomly divided into two groups:group D and group L,20 cases in each group.Group D received continuous infusion of dexmedetomidine 0.5 UG (/kg h) 10 minutes before operation,and the patients'consciousness disappeared. Patients in L group were given midazolam 0.05 mg/kg while infusing lactate Ringer solution 10 minutes before operation. Both groups were given 0.5% lidocaine local anesthesia and routine mask oxygen 3-4 L/min during operation. Heart rate (HR), mean arterial pressure (MAP), oxygen saturation (Sp O2), sedation and pain scores were observed at different time points. HR, MAP and Sp O2 had no significant difference before administration (P 0.05), heart rate and blood pressure increased in group L (P 0.05), sedation score and analgesic effect in group D were significantly better than those in group L (P 0.05), and there was no significant difference in Sp O2 (P 0.05). Conclusion: In this study, dexmedetomidine for ultrasound-guided percutaneous radiofrequency ablation of liver tumors was effective. Safe and effective.
【作者单位】：河北联合大学附属唐山市人民医院;
【基金】：河北省医学科学研究重点课题计划(No.20130674)
【分类号】：R614;R735.7

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