SCN9A基因多态性与妇科腹腔镜手术罗哌卡因局部浸润镇痛效果的相关性研究
发布时间：2018-09-17 07:35
【摘要】：目的探讨SCN9A基因多态性与妇科腹腔镜手术患者罗哌卡因局部浸润镇痛效果的相关性。方法选择择期行妇科腹腔镜手术患者200例,采用随机、对照和双盲的研究方法将患者分为两组,分别在手术切皮前5min在切口部位局部浸润0.75%罗哌卡因12ml(R组)和等量生理盐水(C组),术中均采用TCI丙泊酚血浆靶浓度3μg/ml,瑞芬太尼血浆靶浓度3ng/ml,吸入七氟醚维持麻醉。CO2气腹压维持在≤12mm Hg。记录术后切口部位VAS疼痛评分。抽取外周静脉血2ml提取DNA,应用PCR技术结合DNA直接测序方法分析患者SCN9A基因型。结果 SCN9A基因第15号外显子2794(A/C)基因突变与术后疼痛无明显相关;SCN9A基因第18号外显子3448(C/T)基因突变与术后疼痛存在相关性(P0.05)。结论 SCN9A基因第18号外显子3448(C/T)的杂合突变与术后疼痛的发生具有相关性,但对罗哌卡因的疼痛效果无明显影响。
[Abstract]:Objective to investigate the relationship between SCN9A gene polymorphism and ropivacaine local invasive analgesia in gynecological laparoscopic surgery. Methods 200 patients undergoing gynecological laparoscopic surgery were divided into two groups by randomized, controlled and double-blind study. Before skin incision, 5min infiltrated 0.75% ropivacaine 12ml (group R) and saline (group C). TCI propofol plasma target concentration was 3 渭 g / ml, remifentanil plasma target concentration was 3 ng / ml, sevoflurane was inhaled to maintain anesthesia. CO2 pneumoperitoneum pressure maintained at 鈮，
本文编号：2245177
[Abstract]:Objective to investigate the relationship between SCN9A gene polymorphism and ropivacaine local invasive analgesia in gynecological laparoscopic surgery. Methods 200 patients undergoing gynecological laparoscopic surgery were divided into two groups by randomized, controlled and double-blind study. Before skin incision, 5min infiltrated 0.75% ropivacaine 12ml (group R) and saline (group C). TCI propofol plasma target concentration was 3 渭 g / ml, remifentanil plasma target concentration was 3 ng / ml, sevoflurane was inhaled to maintain anesthesia. CO2 pneumoperitoneum pressure maintained at 鈮，
本文编号：2245177
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