尼可地尔静脉预注射对心肺复苏大鼠脑血流及神经功能的影响

发布时间：2018-09-17 15:54

【摘要】：目的探讨尼可地尔静脉预注射对心肺复苏大鼠脑血流及神经功能的影响。方法 60只Wistar大鼠,将其分为假手术组、对照组、干预组各20只。对照组、干预组建立窒息性心跳骤停复苏大鼠模型;假手术组仅进行麻醉和气管插管、股动静脉置管,不进行夹管窒息及心肺复苏;复苏前,假手术组、对照组股静脉注射1 m L生理盐水,干预组注射1 m L尼可地尔。自主循环恢复6、12、24、48、72 h时每组分别处死4只大鼠,比较各组各时点脑组织含水量、平均动脉压、脑灌注压、脑血流速度、神经功能缺损评分。结果与假手术组自主循环恢复6、12、24、48、72 h相比,对照组、干预组同时点脑组织含水量高,平均动脉压、脑灌注压、脑血流速度、神经功能缺损评分低(P均0.05)。与对照组自主循环恢复6、12、24、48、72 h相比,干预组同时点脑组织含水量低,平均动脉压、脑灌注压、脑血流速度、神经功能缺损评分高(P均0.05)。对照组、干预组自主循环恢复6、12、24、48、72 h脑组织含水量、平均动脉压、脑灌注压、脑血流速度、神经功能缺损评分本组各时间点两两相比P均0.05。结论尼可地尔静脉预注射可显著改善心肺复苏大鼠脑血流状况及神经功能。
[Abstract]:Objective to investigate the effect of nicorandil preinjection on cerebral blood flow and nerve function in cardiopulmonary resuscitation (CPR) rats. Methods 60 Wistar rats were divided into sham operation group, control group and intervention group. In the control group, the rat model of asphyxia cardiac arrest resuscitation was established in the intervention group; in the sham operation group, only anesthesia and tracheal intubation, femoral arteriovenous catheterization, no clamping asphyxia and cardiopulmonary resuscitation were performed; before resuscitation, the sham operation group, 1 mL normal saline was injected into the femoral vein of the control group, and 1 mL nicordil was injected into the intervention group. Four rats were killed in each group after the recovery of spontaneous circulation for 72 hours. The water content of brain tissue, mean arterial pressure, cerebral perfusion pressure, cerebral blood flow velocity and neurological impairment score were compared at each time point. Results compared with the sham operation group, the control group had higher brain water content, mean arterial pressure, cerebral perfusion pressure, cerebral blood flow velocity and neurological deficit score at the same time (P 0.05). Compared with the control group, the cerebral water content, mean arterial pressure, cerebral perfusion pressure, cerebral blood flow velocity and neurological deficit score were higher in the intervention group than in the control group at the same time (P 0.05). In the control group, the brain tissue water content, mean arterial pressure, cerebral perfusion pressure, cerebral blood flow velocity and neurological deficit score were significantly higher than those in the control group (P < 0.05). Conclusion nicorandil intravenous injection can significantly improve cerebral blood flow and neurological function in cardiopulmonary resuscitation rats.
【作者单位】：天津市第五中心医院;华北理工大学附属医院;
【分类号】：R459.7

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