丙泊酚对肝缺血再灌注损伤保护作用的Meta分析
发布时间：2018-10-23 09:42
【摘要】：目的:通过Meta分析评价丙泊酚对肝脏缺血再灌注损伤的保护作用。 方法:按照制定的检索策略系统检索Pub Med、EMBASE、Web of Knowledge、TheCochane Library、中国生物医学文献数据库、万方全文数据库、维普中文科技期刊数据库、中国知网，检索日期截止到2014年2月28日，限中英文语种，并计算机或手工查阅研究中引用的参考文献。按照制定的纳入和排除标准，纳入所有研究丙泊酚麻醉对肝门阻断的肝脏切除术成年病人的肝缺血再灌注影响的随机对照试验，对获得2篇以上相关的全文文献应用RevMan5.2软件进行Meta分析。 结果:共检索到21篇符合纳入标准的文献，共计1097例病例，其中试验组686例，对照组511例。主要的结局指标：肝门阻断末到再开放15min(T1) SOD、MDA、ALT、AST，肝门再开放30-45min(T2) SOD、MDA。术后第1天(T3) ALT、AST，术后第3-4天(T4) ALT、AST。Meta分析结果如下，T1SOD：MD为15.08nU/ml，95%CI为(10.81,19.36) nmol/l，P0.05；T2SOD：MD为24.20nU/ml，95%CI为(17.86,30.53) nmol/l，P0.05；T1MDA：MD为-5.73nmol/l，95%CI为(-7.29,-4.16) nmol/l，P0.05；T2MDA：MD为-5.81nmol/l，95%CI为(-7.84，-2.71) nmol/l，P0.05；T1ALT：MD为-24.46IU/L，95%CI为(-30.86,-18.04)IU/L，P0.05；T3ALT：MD为-31.49IU/L，95%CI为(-36.73,-26.26) IU/L，P0.05；T4ALT：MD为-0.77IU/L，95%CI为(-2.63,1.10) IU/L，P=0.42；T1AST:MD为-23.85IU/L，95%CI为(-29.78,-17.93) IU/L，P0.05；T3AST：MD为-5.85IU/L，95%CI为(-29.14,17.45) IU/L，P=0.62；T4ALT：MD为-2.32IU/L，，95%CI为(-7.29,2.65) IU/L，P=0.36。 结论：丙泊酚对肝门阻断肝切除术的肝缺血再灌注损伤有一定的保护作用。
[Abstract]:Objective: to evaluate the protective effect of propofol on hepatic ischemia reperfusion injury by Meta analysis. Methods: according to the retrieval strategy, Pub Med,EMBASE,Web of Knowledge,TheCochane Library, Chinese Biomedical Literature Database, Wanfang Full-text Database, Weipu Chinese Sci-tech Journals Database, Chinese Journal of Science and Technology, China knowledge Network were searched. The retrieval date was as of February 28, 2014. Limited to Chinese and English languages, and computer or manual reference cited in the study. All randomized controlled trials to study the effects of propofol anesthesia on hepatic ischemia-reperfusion in adult patients undergoing hepatectomy with hilar occlusion were included in accordance with established inclusion and exclusion criteria. RevMan5.2 software was used to analyze more than 2 related articles in Meta. Results: a total of 21 articles, including 686 cases in the experimental group and 511 cases in the control group, were found. Main outcome measures: end of hilar occlusion to reopening 15min (T1) SOD,MDA,ALT,AST, 30-45min (T2) SOD,MDA. 鏈悗绗
本文编号：2288851
[Abstract]:Objective: to evaluate the protective effect of propofol on hepatic ischemia reperfusion injury by Meta analysis. Methods: according to the retrieval strategy, Pub Med,EMBASE,Web of Knowledge,TheCochane Library, Chinese Biomedical Literature Database, Wanfang Full-text Database, Weipu Chinese Sci-tech Journals Database, Chinese Journal of Science and Technology, China knowledge Network were searched. The retrieval date was as of February 28, 2014. Limited to Chinese and English languages, and computer or manual reference cited in the study. All randomized controlled trials to study the effects of propofol anesthesia on hepatic ischemia-reperfusion in adult patients undergoing hepatectomy with hilar occlusion were included in accordance with established inclusion and exclusion criteria. RevMan5.2 software was used to analyze more than 2 related articles in Meta. Results: a total of 21 articles, including 686 cases in the experimental group and 511 cases in the control group, were found. Main outcome measures: end of hilar occlusion to reopening 15min (T1) SOD,MDA,ALT,AST, 30-45min (T2) SOD,MDA. 鏈悗绗
本文编号：2288851
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