不同性别对腹部手术全身麻醉患者单次静脉注射丙泊酚的药代动力学影响研究

发布时间：2018-10-23 13:00

【摘要】：目的探讨不同性别对腹部手术全身麻醉患者单次静脉注射丙泊酚的药动学影响。方法选择2012年5月-2013年5月来该院就诊并实施腹部全身麻醉手术患者36例,按照不同性别将其分为男性组和女性组,每组各18例。两组患者均采用静吸复合麻醉,分别于注射丙泊酚后的1、2、3、4、5、10、15、30、45、60、90、120、150、180、240、360和720 min时抽取3 ml静脉血,血浆丙泊酚浓度使用高效液相色谱-荧光检测法测定,并以上述时间点为时间轴绘制血药浓度-时间曲线,分别计算两组患者药代动力学参数。结果两组患者血药浓度均快速下降,但女性组腹部手术全身麻醉患者在10 min以内的各个时间点的血药浓度均显著低于男性组,差异有统计学意义(P0.05)。10 min以后的各个时间点两组患者的血药浓度差异无统计学意义;女性组中央式分布容积(Vc)和清除率(CL)显著高于男性组,差异有统计学意义(P0.05),两组患者的其他药代动力学参数组间比较差异无统计学意义(P0.05)。结论对全麻患者静脉注射丙泊酚后,女性患者在各个时间点采集的血药浓度均低于男性患者,中央式分布容积(Vc)和清除率(CL)女性患者显著高于男性,表明不同性别对腹部手术全麻病人单次静脉注射丙泊酚的药代动力学有明显的影响。
[Abstract]:Objective to investigate the pharmacokinetics of propofol by single intravenous injection of propofol in patients undergoing general anesthesia during abdominal surgery. Methods from May 2012 to May 2013, 36 patients with abdominal general anesthesia were selected and divided into male group and female group, 18 cases in each group. Patients in both groups were anesthetized by intravenous inhalation. Plasma propofol concentrations were determined by high performance liquid chromatography (HPLC) and fluorescence detection (HPLC) after injection of propofol. Three ml venous blood samples were drawn from the patients with propofol at the time of injection of propofol at 10153030, 6090120150180240360 and 720 min, respectively, and the plasma propofol concentration was determined by high performance liquid chromatography (HPLC) and fluorescence detection. The pharmacokinetic parameters of the two groups were calculated by drawing the blood concentration-time curve on the time axis. Results the blood drug concentration of the two groups decreased rapidly, but the blood drug concentration of the female group was significantly lower than that of the male group at every time point within 10 min after abdominal operation. There was no significant difference in blood drug concentration between the two groups after 10 min (P0.05). The central distributed volume (Vc) and clearance (CL) of female group were significantly higher than that of male group. The difference was statistically significant (P0.05). There was no significant difference in other pharmacokinetic parameters between the two groups (P0.05). Conclusion after intravenous injection of propofol, the serum concentration of propofol in female patients was significantly lower than that in male patients at all time points, and the central distributed volume (Vc) and clearance rate (CL) in female patients were significantly higher than those in male patients. The results showed that different genders had significant effect on the pharmacokinetics of propofol in patients with general anesthesia during abdominal surgery.
【作者单位】：辽宁医学院附属第三医院手术室;辽宁医学院附属第三医院麻醉科;
【分类号】：R614

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