生长抑素联合吲哚美辛预防ERCP术后胰腺炎的研究

发布时间：2018-10-24 13:14

【摘要】：目的探讨生长抑素联合吲哚美辛在预防内镜逆行胰胆管造影技术(ERCP)术后胰腺炎(PEP)及高淀粉酶血症中的作用。方法将120例ERCP患者按随机数字表法分为生长抑素单药预防(A)组、吲哚美辛单药预防(B)组和生长抑素与吲哚美辛联合用药(C)组,每组各40例。3组患者行常规麻醉,A组:术前30min给予生长抑素250μg静脉注射,术后给予生长抑素250μg·h-1泵入11h;B组:术前30 min直肠给予0.1g吲哚美辛栓剂;C组:术前30min给予生长抑素250μg静脉注射,术后给予生长抑素250μg·h-1泵入11h+术前30min直肠给予0.1g吲哚美辛栓剂。术前2h和术后3、24h检测血清淀粉酶水平,比较3组ERCP术后高淀粉酶血症及PEP发生率。结果 ERCP术后3、24h,A、B 2组间血清淀粉酶比较差异无统计学意义,C组血清淀粉酶明显低于A、B组(均P0.05);C组高淀粉酶血症和PEP发生率明显低于A、B组(均P0.05)。结论吲哚美辛联合生长抑素能够较使用单一药物取得更佳的PEP防治效果。
[Abstract]:Objective to investigate the role of somatostatin combined with indomethacin in the prevention of (PEP) and hyperamylase after endoscopic retrograde cholangiopancreatography (ERCP). Methods 120 patients with ERCP were randomly divided into three groups: somatostatin single drug prophylaxis (A) group, indomethacin single drug prophylaxis (B) group and somatostatin combined with indomethacin (C) group. 40 patients in each group were given routine anesthesia. Group A received 30min 250 渭 g intravenously before operation. Postoperatively, somatostatin 250 渭 g h-1 was pumped into 11hmb group: 30 min before operation, 0.1 g indomethacin suppository was given to rectum in group C: 30min 250 渭 g intravenously before operation and 0.1 g indomethacin suppository in rectum before 11 h pump of somatostatin 250 渭 g h-1. Serum amylase levels were measured 2 hours before and 3 hours after ERCP, and the incidence of hyperamylase and PEP were compared among the three groups. Results there was no significant difference in serum amylase in group C (P 0.05), and the incidence of hyperamylase and PEP (P 0.05) in group C was significantly lower than that in group A (P 0.05). Conclusion Indomethacin combined with somatostatin is more effective than single drug in the prevention and treatment of PEP.
【作者单位】：高邮市人民医院消化内科;
【分类号】：R57

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