不同麻醉方案对颅内动脉瘤介入手术患者氧化应激反应的影响

发布时间：2018-11-13 06:31

【摘要】：目的比较不同麻醉方案对颅内动脉瘤介入手术患者氧化应激反应的影响。方法行介入手术的120例患者,分为异丙酚组(60例)和七氟烷组(60例)。记录心率和平均动脉压,检测麻醉前(T0)、术后6h(T1)、24h(T2)、48h(T3)、72h(T4)的过氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)与术后3个月格拉斯哥预后评分(GOS)。结果(1)两组患者在T2和T3的SOD、CAT、GSH-Px活性显著低于术前(P0.05)。(2)异丙酚组SOD在T1~T4显著高于七氟烷组(P0.05),CAT在T1、T2上高于七氟烷组(P0.05),GSH-Px活性在T1~T3显著高于七氟烷组(P0.05)。(3)两组的预后差异无统计学意义(P0.05)。结论与七氟烷相比,异丙酚麻醉能更好地对抗颅内动脉瘤介入手术患者的氧化应激反应。
[Abstract]:Objective to compare the effects of different anesthetic schemes on oxidative stress in patients undergoing interventional surgery for intracranial aneurysms. Methods 120 patients undergoing interventional surgery were divided into propofol group (n = 60) and sevoflurane group (n = 60). Heart rate and mean arterial pressure were recorded, (SOD), of peroxidase dismutase was measured before anesthesia (T 0), 6 h (T 1), 24 h (T 2), 48 h (T 3), 72 h (T 4). Relationship between catalase (CAT) and glutathione peroxidase (GSH-Px) and Glasgow prognosis score (GOS).) 3 months after operation Results (1) the SOD,CAT,GSH-Px activity in T2 and T3 in both groups was significantly lower than that in preoperative (P0.05). (2), SOD in propofol group was significantly higher than that in sevoflurane group (P0.05), CAT on T2 was higher than that in sevoflurane group (P0.05). The activity of GSH-Px in T1~T3 group was significantly higher than that in sevoflurane group (P0.05). (3). There was no significant difference in prognosis between the two groups (P0.05). Conclusion compared with sevoflurane, propofol anesthesia is more effective against oxidative stress in patients undergoing interventional surgery for intracranial aneurysms.
【作者单位】：河北医科大学第一医院麻醉科;河北医科大学第一医院神经内科;
【基金】：河北省科技计划项目(112761126)
【分类号】：R614.2

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