顺苯磺阿曲库铵在手术治疗挤压伤患者全身麻醉诱导及维持中的应用

发布时间：2018-11-20 14:42

【摘要】：目的观察顺苯磺阿曲库铵在挤压伤手术全身麻醉诱导及维持中的应用效果。方法挤压伤患者80例,随机分为观察组和对照组各40例。两组均使用芬太尼、丙泊酚麻醉诱导,观察组加用顺苯磺阿曲库铵诱导及丙泊酚、顺苯磺阿曲库铵联合泵入维持麻醉深度;对照组使用维库溴铵诱导及丙泊酚、维库溴铵泵入维持麻醉深度。观察两组肌松监测指标T125%、T175%、T190%恢复时间及麻醉前后肾功能指标(血尿素氮、肌酐)变化,比较两组尿比重增高、肌红蛋白尿和高钾血症的发生率。结果两组患者术中生命体征均平稳,手术均顺利进行,未发生麻醉并发症。观察组T125%、T175%、T190%恢复时间快于对照组(P均0.05),恢复指数低于对照组(P0.05)。对照组苏醒后血尿素氮、肌酐水平高于同组麻醉前及观察组(P均0.05)。观察组尿比重增高、肌红蛋白尿、高钾血症发生率低于对照组(P均0.05)。结论顺苯磺阿曲库铵用于挤压伤手术全身麻醉诱导及维持效果较好,对患者术后肌松消退时间及肾功能影响较小,不增加围麻醉期并发症。
[Abstract]:Objective to observe the effect of cisbenesulfonate atracurium on induction and maintenance of general anesthesia in crush injury. Methods 80 patients with crush injury were randomly divided into observation group and control group. Both groups were induced by fentanyl and propofol, while in the observation group, the anesthetic depth was maintained by adding cisbenzenesulfonatracurium, propofol and cisbenzenesulfonatracurium. The control group was treated with vecuronium induced and propofol, and vecuronium was pumped into the anesthetic depth. The recovery time of T125 and T175% and the changes of renal function (blood urea nitrogen, creatinine) before and after anesthesia were observed. The urinary specific gravity, the incidence of myoglobin and hyperkalemia were compared between the two groups. Results the vital signs of the two groups were stable, the operation was smooth, and no anesthetic complications occurred. The recovery time of T125 and T175% in the observation group was faster than that in the control group (P 0.05), and the recovery index was lower than that in the control group (P0.05). The levels of blood urea nitrogen and creatinine in the control group were higher than those in the control group before anesthesia and in the observation group (P 0.05). The incidence of urinary specific gravity, myoglobin and hyperkalemia in the observation group was lower than that in the control group (P 0.05). Conclusion the effect of cisbenesulfonate atracurium on the induction and maintenance of general anesthesia in patients with crush injury is good. It has little effect on postoperative time of muscle relaxation and renal function and does not increase perianaesthesia complications.
【作者单位】：长沙市中心医院;
【分类号】：R614.2

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