右美托咪定对妇科手术麻醉诱导期舒芬太尼镇痛和镇静效果的影响
发布时间：2018-12-07 18:36
【摘要】：目的:对右美托咪定在妇科手术麻醉诱导期舒芬太尼镇痛和镇静效果的影响进行研究分析。方法:随机选取80例需行妇科手术的病例,分为对照组和观察组各40例。对照组采用舒芬太尼和生理盐水,观察组采用舒芬太尼和右美托咪定(Dex),对两组在用药前(A1)、用药后(A2)、最高清醒程度时(A3)和用舒芬太尼5min后(A4)的镇痛与镇静效果进行分析。结果:在A2时观察组NTI比对照组A2时低,两组在A2、A4时NTI值都明显低于同组的A1时,在NTI值降至最低时观察组所用时间明显短于对照组,两组A4时的PTO和PPT都明显高于同组A1时,但观察组在A1和A4时PTO和PPT差值明显高于对照组,在恶心、发冷和呕吐等不良反应上观察组同样低于对照组,差异具有统计学意义(P0.05)。结论:Dex对妇科手术麻醉诱导期舒芬太尼镇痛和镇静都有很好的作用,还能使镇静作用更为快速,不良反应也较单独用舒芬太尼少,在使用时还是应注意对不良反应的干预。
[Abstract]:Aim: to study the effect of dexmetomidine on analgesia and sedation of sufentanil during the induction of gynecological anesthesia. Methods: 80 cases of gynecologic operation were randomly divided into control group and observation group. The control group was treated with sufentanil and normal saline, the observation group was treated with sufentanil and dexmetomidine (Dex), before (A1) and after administration (A2). The analgesic and sedative effects were analyzed at maximum waking level (A 3) and after sufentanil 5min (A 4). Results: the NTI of the observation group was lower than that of the control group at A2, the NTI value of both groups was significantly lower than that of the control group at A2A4, and the time of the observation group at the lowest NTI value was significantly shorter than that in the control group. PTO and PPT in A4 group were significantly higher than those in A4 group, but the difference of PTO and PPT in A4 group was significantly higher than that in control group, and in adverse reactions such as nausea, chilling and vomiting, the difference of PTO and PPT in observation group was also lower than that in control group. The difference was statistically significant (P0.05). Conclusion: Dex has a good effect on the analgesia and sedation of sufentanil during the induction period of gynecological anesthesia, and can also make the sedation effect more rapid, and the adverse reaction is less than that of sufentanil alone, so we should pay attention to the intervention of the adverse reaction in the use of sufentanil.
【作者单位】： 郑州大学附属洛阳中心医院
【分类号】：R614
[Abstract]:Aim: to study the effect of dexmetomidine on analgesia and sedation of sufentanil during the induction of gynecological anesthesia. Methods: 80 cases of gynecologic operation were randomly divided into control group and observation group. The control group was treated with sufentanil and normal saline, the observation group was treated with sufentanil and dexmetomidine (Dex), before (A1) and after administration (A2). The analgesic and sedative effects were analyzed at maximum waking level (A 3) and after sufentanil 5min (A 4). Results: the NTI of the observation group was lower than that of the control group at A2, the NTI value of both groups was significantly lower than that of the control group at A2A4, and the time of the observation group at the lowest NTI value was significantly shorter than that in the control group. PTO and PPT in A4 group were significantly higher than those in A4 group, but the difference of PTO and PPT in A4 group was significantly higher than that in control group, and in adverse reactions such as nausea, chilling and vomiting, the difference of PTO and PPT in observation group was also lower than that in control group. The difference was statistically significant (P0.05). Conclusion: Dex has a good effect on the analgesia and sedation of sufentanil during the induction period of gynecological anesthesia, and can also make the sedation effect more rapid, and the adverse reaction is less than that of sufentanil alone, so we should pay attention to the intervention of the adverse reaction in the use of sufentanil.
【作者单位】： 郑州大学附属洛阳中心医院
【分类号】：R614
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