静脉输注利多卡因对腹腔镜全子宫切除术后疼痛及早期康复的影响

发布时间：2018-12-14 18:48

【摘要】：目的观察静脉输注利多卡因对腹腔镜全子宫切除术后疼痛及早期康复的影响。方法96例择期行腹腔镜全子宫切除术的患者,随机分为研究组和对照组,每组48例。研究组麻醉诱导时静脉给予2%利多卡因1.5mg/kg,随后连续静脉输注利多卡因2mg·kg~(-1)·h(-1)直至手术结束,对照组以生理盐水代替利多卡因。记录术后6、12、24和48h静息与咳嗽状态下VAS评分,48h内吗啡累积使用量,术后第一次排气时间,术后第3~5天每天六分钟步行测试距离,以及术后恶心、呕吐、眩晕等不良反应情况。结果术后6、12和24h静息状态下研究组VAS评分明显低于对照组(P0.05);术后48h内各时点咳嗽状态下研究组VAS评分明显低于对照组(P0.05)。与对照组比较,研究组48h内吗啡累积使用量明显减少(P0.05),术后第一次排气时间明显缩短(P0.05),步行测试距离明显延长(P0.05)。两组术后不良反应差异无统计学意义。结论静脉输注利多卡因可以减轻腹腔镜全子宫切除术后疼痛,减少吗啡用量,促进患者早期康复。
[Abstract]:Objective to observe the effect of intravenous lidocaine on pain and early recovery after laparoscopic hysterectomy. Methods 96 patients undergoing laparoscopic hysterectomy were randomly divided into study group and control group with 48 cases in each group. In the study group, 2% lidocaine was given intravenously at 1.5 mg / kg during anesthesia induction, and then lidocaine (-1) h (-1) was continuously infused intravenously until the end of the operation. In the control group, normal saline was used instead of lidocaine. The VAS scores of rest and cough at 24 and 48 hours after operation, the cumulative use of morphine within 48 hours, the first time of exhaust after operation, the walking distance of 6 minutes per day on the 3rd day of operation, and the adverse reactions such as nausea, vomiting and vertigo were recorded. Results the VAS score of the study group was significantly lower than that of the control group (P0.05), and the VAS score of the study group was significantly lower than that of the control group (P0.05) under the cough state at every time point within 48 hours after operation (P0.05). Compared with the control group, the cumulative use of morphine decreased significantly in the study group within 48 hours (P0.05), the first time of exhaust after operation was significantly shortened (P0.05), and the distance of walking test was significantly prolonged (P0.05). There was no significant difference in postoperative adverse reactions between the two groups. Conclusion intravenous infusion of lidocaine can relieve the pain after laparoscopic hysterectomy, reduce the dosage of morphine, and promote the early recovery of patients.
【作者单位】：南京中医药大学附属江苏省中医院麻醉科;
【分类号】：R614

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